Protein Alignment Gyc89Db and NPR1

DIOPT Version :9

• Sequence 1: NP_650551.1
• Gene: Gyc89Db / 42002
• FlyBaseID: FBgn0038436
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_000897.3
• Gene: NPR1 / 4881
• HGNCID: 7943
• Length: 1061
• Species: Homo sapiens
• Alignment Length: 590
• Identity: 159/590 - (26%)
• Similarity: 260/590 - (44%)
• Gaps: 130/590 - (22%)

  Fly   135 SGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLTEGPLTVIVKYRLDFDNR 199
            |||.  |.|  |.:.....:|.....|||...:...:.......|:||...|..: |:..|..|
Human   534 SGRG--SNY--GSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFEL-KHMRDVQN- 592

  Fly   200 DYMAKRVNVIAHPSQLKM-----PSVDLNVFLELFPFTIVLDHDMKITLAGEKIVETWILHNPGV 259
            :::.:.|.....|..:.:     |...|...||  ..:|.||...:.:|..:.:.....|||..
Human   593 EHLTRFVGACTDPPNICILTEYCPRGSLQDILE--NESITLDWMFRYSLTNDIVKGMLFLHNGA- 654

  Fly   260 NPKTFIGSH-ILERFKCRRPKDTQIQWETILQMRTVLFEFELIRTGHNRAAYDAALNFDFENFDE 323
                 |.|| .|:...|            ::..|.||                ...::..|:|.:
Human   655 -----ICSHGNLKSSNC------------VVDGRFVL----------------KITDYGLESFRD 686

  Fly   324 ASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATGQRR---HSVG--LRSILLKGQMF 383
               |:..|...:.:.|.::|......|:         .|..|.:.   :|.|  |:.|.|:..:|
Human   687 ---LDPEQGHTVYAKKLWTAPELLRMAS---------PPVRGSQAGDVYSFGIILQEIALRSGVF 739

  Fly   384 YIKDVDSLIFLCSP--LIENL---------------DELHGIGLYL------------------- 412
            :::.:|     .||  :||.:               ..|..:||.:
Human   740 HVEGLD-----LSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIRL 799

  Fly   413 -----NDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIP 472
                 |..|...:...|:....|:.:.||.:.|:..|.  .||:        ||:.:.|||.::|
Human   800 TLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQA--YLEE--------KRKAEALLYQILP 854

  Fly   473 RPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYDSGSNNIQDAMQAVTTLNKVFSALDEEIISPFV 537
            ..:||::::.|....::|:.|::.|.:::......:.:  ..||.||.||.:::..|..|.:..|
Human   855 HSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAES--TPMQVVTLLNDLYTCFDAVIDNFDV 917

  Fly   538 YKVETVGMVYMAVSGAPDVN-PLHAEHACDLALRVMKKVKAHAL-----PGVAIRVGINSGPVVA 596
            |||||:|..||.|||.|..| .|||.....:||.::..|::..:     ..:.:|:||::|||.|
Human   918 YKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCA 982

  Fly   597 GVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQKV-GYKVEARGFVKVKGKGEME 660
            ||||:|:||||||||||||||||||:.:...|.||:.|...:::. |:::|.||.|::||||::.
Human   983 GVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVR 1047

  Fly   661 TYWLL 665
            |||||
Human  1048 TYWLL 1052

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	7/25 (28%)
		HNOBA	218..479	CDD:400168	60/307 (20%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	77/183 (42%)
NPR1	NP_000897.3	PBP1_NPR_A	36..443	CDD:107380
		ANF_receptor	54..414	CDD:279440
		PK_GC-A_B	534..807	CDD:270944	62/331 (19%)
		TyrKc	547..801	CDD:197581	55/308 (18%)
		HNOBA	<816..861	CDD:285003	16/54 (30%)
		CYCc	840..1032	CDD:214485	76/201 (38%)
		Guanylate_cyc	867..1053	CDD:278633	79/188 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810