DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Db and CG31183

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster

Alignment Length:	781	Identity:	182/781 - (23%)
Similarity:	295/781 - (37%)	Gaps:	246/781 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YESVQHYIQQEYGMETWRKVCQIVDCKHQSFKTHQIYPDK--------LMPDFA----AALSAST 58
            :|.|.|::......|..:::       |.:....:..||:        |.||.:    |.||...
  Fly   477 FEIVAHFLHNRLEFEANKEI-------HWAGDREEAPPDRPICGYDGALCPDNSLPGYAILSIVL 534

  Fly    59 GESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQ------MRFTYPKMKSP 117
            |.    .:.....||.     |||...|.........:..|::::..:      :|.::..:...
  Fly   535 GT----MVVVMAVCFF-----FGYRHYIAEAEINSMSWKVSLEDVMFRDAAERGLRGSFHSLVKQ 590

  Fly   118 SMQLTNMDDDGAVI-----------LYRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDI 171
            |.|||.|.:|...|           ::|..:..:.
  Fly   591 SSQLTLMSEDMVSINGDRQIFIPVGMFRKSKVAIK------------------------------ 625

  Fly   172 CGGTAGPIKL--TEGPLTVIVKYRLDFDNRDYMAKRVNVIAHPSQLKM----------------- 217
                  |:::  .:|.||..:...|         ||:..:.|...:|.
  Fly   626 ------PVEVDNVQGLLTRSLMLEL---------KRMKDLQHDHLVKFYGACLDQRRSFLLTEYC 675

  Fly   218 PSVDLNVFLELFPFTIVLDHDMKITLAGEKIVETWILHNPGV----NPK--------------TF 264
            |...|...||...|.  ||...:::|..:.:.....||:..:    |.|              |.
  Fly   676 PKGSLQDILENEQFQ--LDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITD 738

  Fly   265 IGSHILERFKCRRPKD-----TQIQWETILQMRTVLFEFELIRTGHNRAAYDAALNFDFENFDEA 324
            .|.|.|.|.:.....|     :...|..:|....     ||:|..|||.             .|.
  Fly   739 FGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAP-----ELLRVEHNRP-------------PEG 785

  Fly   325 SSLNEAQAMAL---------------ASAKEFSAENAKE----------------EAAAAATSKD 358
            :...:..|..:               ..|.|.|.:...|                |......:|.
  Fly   786 TQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKA 850

  Fly   359 EI----------DPATGQRRHSVGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLN 413
            :|          |||  :|.....|:|::.:    :.||.::     ..:::||  |..:.||.|
  Fly   851 DINGIIRRCWAEDPA--ERPDFNTLKSMIRR----FNKDNET-----GNIVDNL--LKRMELYAN 902

  Fly   414 DLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAER 478
            :|      .|||                ||:..|..|:        |::.::|||.::|:.:|.:
  Fly   903 NL------EELV----------------EERTQDYHEE--------KKKCEKLLYQLLPQSVAAQ 937

  Fly   479 MRKSEEHVCQSFEEVSVIFIEVMNIYDSGSNNIQDAMQAVTTLNKVFSALDEEIISPFVYKVETV 543
            :...:..|.::|::|::.|.:::......:.:  ..||.|..||.:::..|..:.:..||||||:
  Fly   938 LISGQPVVAETFDQVTIYFSDIVGFTAISAES--TPMQVVQFLNDLYTCFDSIVENFDVYKVETI 1000

  Fly   544 GMVYMAVSGAPDVN-PLHAEHACDLALRVMKKV---KAHALP--GVAIRVGINSGPVVAGVVGMK 602
            |..||.|||.|..| ..||.....|||.:::.|   :.|..|  .:.:|:|:::|..||||||:|
  Fly  1001 GDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLK 1065

  Fly   603 VPRYCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQKVG-YKVEARGFVKVKGKGEMETYWLLE 666
            :||||||||||||||||||:.:...|.:|..|...:.:.| :....||||.:||||||.||| ||
  Fly  1066 MPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYW-LE 1129

  Fly   667 G 667
            |
  Fly  1130 G 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	30/183 (16%)
		HNOBA	218..479	CDD:400168	63/324 (19%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	76/183 (42%)
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	4/27 (15%)
		ANF_receptor	108..473	CDD:279440
		PK_GC-A_B	589..883	CDD:270944	58/364 (16%)
		Pkinase_Tyr	613..877	CDD:285015	51/330 (15%)
		HNOBA	<893..938	CDD:285003	19/76 (25%)
		CYCc	917..1108	CDD:214485	71/200 (36%)
		Guanylate_cyc	944..1130	CDD:278633	78/188 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454050
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740