DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gyc89Db and GUCY2C

DIOPT Version :9

Sequence 1:NP_650551.1 Gene:Gyc89Db / 42002 FlyBaseID:FBgn0038436 Length:669 Species:Drosophila melanogaster
Sequence 2:NP_004954.2 Gene:GUCY2C / 2984 HGNCID:4688 Length:1073 Species:Homo sapiens


Alignment Length:768 Identity:188/768 - (24%)
Similarity:309/768 - (40%) Gaps:189/768 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 QIYPDKL-MPDF---AAALSASTGESF---DFCMNF------FGRCFVRFFSNFGYDKMIRSTGR 91
            |.:.|.: .||:   ...|:.|.|.|.   .|..|.      |...::.....||:...|     
Human   279 QYFEDNVTAPDYMKNVLVLTLSPGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKI----- 338

  Fly    92 YFCDFLQSIDNIHVQMRFTYPKMKSPSMQLT--------NMDDDG-----AVILYRSGRTGMSKY 143
                ||::.:||      |.||.......||        .:||.|     .|:||.|..|...|.
Human   339 ----FLENGENI------TTPKFAHAFRNLTFEGYDGPVTLDDWGDVDSTMVLLYTSVDTKKYKV 393

  Fly   144 LIGQMTEVAKEFYGLDMT-AYVLESQ---NDICGG------------TAGPIKLTEGPLTVIVKY 192
            |:...|.|.|. |.:||: .:..::.   |||.|.            |...:.|....|.::.||
Human   394 LLTYDTHVNKT-YPVDMSPTFTWKNSKLPNDITGRGPQILMIAVFTLTGAVVLLLLVALLMLRKY 457

  Fly   193 RLDFDNRDYMAKRVNVIAHPSQLKMPSVDLNVFLELFPFTIVLDHDMK---------ITLAGEKI 248
            |.|::.|......:     |.:...| ::.|   |....::.:|.|.:         .....:::
Human   458 RKDYELRQKKWSHI-----PPENIFP-LETN---ETNHVSLKIDDDKRRDTIQRLRQCKYDKKRV 513

  Fly   249 VETWILHNPGVNPKTFIGSHILERFKCRRPKDTQIQWETI------LQMRTVLF-EFELIRTGHN 306
            :...:.||.|         :..|:.|....|..||.:..:      :::.|::| ..|....|..
Human   514 ILKDLKHNDG---------NFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSL 569

  Fly   307 RAAYDAALNF------DFENFDEASSLNEAQAMA-LASAK-----------------------EF 341
            |...:..:::      |:| |..:...:.|:.|: |.|:|                       :|
Human   570 REVLNDTISYPDGTFMDWE-FKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDF 633

  Fly   342 SAENAKEEAAAAATSKDEIDPATGQRR---HSVGL--RSILLKGQMFY---IKDVDSLIFLCSPL 398
            ...:.........|:.:.:..|...::   :|.|:  :.|:|:.:.||   .:|.:..||    .
Human   634 GCNSILPPKKDLWTAPEHLRQANISQKGDVYSYGIIAQEIILRKETFYTLSCRDRNEKIF----R 694

  Fly   399 IENLDELHGI--GLYLNDLNPHGLSRELVMAG-WQH--------------CSKLEIMF--EKEEQ 444
            :||.:.:...  .|:|.......|...|::.. |:.              .:|:..:|  :|.|.
Human   695 VENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNES 759

  Fly   445 RSDEL---------------EKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVS 494
            ..|.|               |:..:|..:.:.:.|.|.:.::||.:.:.:::......:.:|||:
Human   760 YMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVT 824

  Fly   495 VIFIEVMNIYDSGSNNI---QDAMQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDV 556
            :.|.:::     |...|   ...|:.|..||.::.:.|..:....||||||:|..||..||.|..
Human   825 IYFSDIV-----GFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKR 884

  Fly   557 NPLHAEHACDLA------LRVMKKVKAHALPG--VAIRVGINSGPVVAGVVGMKVPRYCLFGDTV 613
            |  ...||.|:|      |..|...:...|||  :.||:|::|||..|||||:|:||||||||||
Human   885 N--GNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTV 947

  Fly   614 NTASRMESSSDPWMIQLSNYT--ALKVQKVGYKVEARGFVKVKGKGEMETYWL 664
            ||||||||:..|..|.:|..|  .||..:..:..|.||...:||:|...||||
Human   948 NTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWL 1000

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc89DbNP_650551.1 HNOB 2..161 CDD:400167 38/146 (26%)
HNOBA 218..479 CDD:400168 57/348 (16%)
Nucleotidyl_cyc_III 488..665 CDD:416391 79/190 (42%)
GUCY2CNP_004954.2 PBP1_GC_C_enterotoxin_receptor 35..415 CDD:107364 39/151 (26%)
PK_GC-C 480..750 CDD:270946 45/286 (16%)
Pkinase_Tyr 502..745 CDD:285015 40/256 (16%)
CYCc 788..979 CDD:214485 73/197 (37%)
Guanylate_cyc 815..1002 CDD:278633 79/193 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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