Protein Alignment Gyc89Db and GUCY1A2

DIOPT Version :10

• Sequence 1: NP_650551.1
• Gene: Gyc89Db / 42002
• FlyBaseID: FBgn0038436
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_001243353.1
• Gene: GUCY1A2 / 2977
• HGNCID: 4684
• Length: 763
• Species: Homo sapiens
• Alignment Length: 696
• Identity: 160/696 - (22%)
• Similarity: 297/696 - (42%)
• Gaps: 169/696 - (24%)

  Fly     5 LYESVQHYIQQEYGMETWRKVCQIVDCKHQSFKTHQI-----YPD----KLMPDFAAALSAST-- 58
            |..::|:|..|..|.....|            ..|.|     |.|    :.:.|.:..|..:.
Human   109 LKRTLQYYEHQVIGYRDAEK------------NFHNISNRCSYADHSNKEEIEDVSGILQCTANI 161

  Fly    59 -GESFDFCMNFFGRCF--VRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPK---MKSP 117
             |..|:.....||..|  :.|..|   ::::|:.|....||....|.:...:|.::.|   ::||
Human   162 LGLKFEEIQKRFGEEFFNICFHEN---ERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQATLESP 223

  Fly   118 SMQLTNMDDDGAVILYRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLT 182
            |.....:.:...::.|......:...::|.:....|:.|.||:....:.::. :|...:.|...:
Human   224 SFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYRLDVEVEQVANEK-LCSDVSNPGNCS 287

  Fly   183 EGPLTVIVKYRLDFDNRDYMAKRVNVIAH-PSQLKMPSVDLNVFLELFPFTIVLDHDMKITLAGE 246
              .||.::|   :.:|.:.|.......:. |:.|:   :.:|.|...|||.::.|..|.:...||
Human   288 --CLTFLIK---ECENTNIMKNLPQGTSQVPADLR---ISINTFCRAFPFHLMFDPSMSVLQLGE 344

  Fly   247 KIVETWILHNPGVNPKTFIGSHILERFKCRRPKDTQIQWETILQMRTVLFE--FELIRTGHNRAA 309
                                 .:.::.:|    ||.         :.:.||  ||::
Human   345 ---------------------GLRKQLRC----DTH---------KVLKFEDCFEIV-------- 367

  Fly   310 YDAALNFDFENFDEASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATGQRRHSVGLR 374
             ...:|..||.            :.|..:..|......|  |:.:.:||::
Human   368 -SPKVNATFER------------VLLRLSTPFVIRTKPE--ASGSENKDKV-------------- 403

  Fly   375 SILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMF 439
             :.:||||.::.:.:|::||.||.::.||||.|.||:|:|:..|..:|::::.|.|  :|.:...
Human   404 -MEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQ--AKAQDGL 465

  Fly   440 EKEEQRSDELEKSLE----LADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEV 500
            :|   |.|:|:.:||    ..:..|::..:||||:.|..:|:::.:.::...:.|::|:::|.::
Human   466 KK---RMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDI 527

  Fly   501 MNIYDSGSNNI---QDAMQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAE 562
            :     |...|   ...||.::.||::::..|.:.....:|||||:|..|...:|....:..||:
Human   528 V-----GFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAK 587

  Fly   563 HACDLALRVMK------------------------KVKAHALPG----------VAIRVGINSGP 593
            ....:||::|:                        .|....:|.          ..:|:||:||.
Human   588 PIALMALKMMELSEEVLTPDGRPIQPQRSELLFSFPVSIQLVPDQHQSETDLGTEKMRIGIHSGS 652

  Fly   594 VVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLS--NYTALK 637
            |:|||||:::|||||||:.|..||:.||.|.|..|.:|  .|..||
Human   653 VLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLK 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:462233	35/172 (20%)
		HNOBA	218..479	CDD:462234	61/266 (23%)
		Nucleotidyl_cyc_III	488..665	CDD:448371	55/189 (29%)
GUCY1A2	NP_001243353.1	HNOB	<159..270	CDD:462233	23/113 (20%)
		HNOBA	316..503	CDD:462234	61/266 (23%)
		Guanylate_cyc	514..729	CDD:425528	55/190 (29%)