Protein Alignment Gyc89Db and Adcy8

DIOPT Version :9

• Sequence 1: NP_650551.1
• Gene: Gyc89Db / 42002
• FlyBaseID: FBgn0038436
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_058838.1
• Gene: Adcy8 / 29241
• RGDID: 2036
• Length: 1248
• Species: Rattus norvegicus
• Alignment Length: 423
• Identity: 111/423 - (26%)
• Similarity: 193/423 - (45%)
• Gaps: 70/423 - (16%)

  Fly   285 W--ETILQMRTVLFEFELIRTGHNRAAYDAALNFDFENFDEASSLNEAQAMALASAKEFSAENAK 347
            |  ||.|....::|...||.      ...|.:|..:.:||::..|..   :...|:..|:...:.
  Rat   774 WINETYLARNVIIFASILIN------FLGAVINILWCDFDKSIPLKN---LTFNSSAVFTDICSY 829

  Fly   348 EEAAAAATSKDEIDPATGQRRHSVGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYL 412
            .|..........:..|...|.:||...::||           .:|.:.:.|.|.:  ..|:.|..
  Rat   830 PEYFVFTGVLAMVTCAVFLRLNSVLKLAVLL-----------IMIAIYALLTETI--YAGLFLSY 881

  Fly   413 NDLNPHG------------LSRELVMAGWQHCSKLE----IMFEKEEQRSDELEKSLELADSWKR 461
            ::||..|            |....::|.:.|..:||    :.|....|..:|:.:..:|    :.
  Rat   882 DNLNHSGEDFLGTKEASLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKDL----RE 942

  Fly   462 QGDELLYSMIPRPIA----ERMRKSEEHVCQSFEEVSVIFIEVMNIYDSGS----NNIQDAMQAV 518
            ..:.:|.:::|..:|    |:.|.:||...||::.|.|:|..:....|..|    ||  ..::.:
  Rat   943 HNENMLRNILPGHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNN--QGVECL 1005

  Fly   519 TTLNKVFSALDE---EIISPFVYKVETVGMVYMAVSG-APDVNPLHAE--HACDLA------LRV 571
            ..||::.:..||   |.....:.|::|:|..|||||| :|:......:  |.|.||      ...
  Rat  1006 RLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTES 1070

  Fly   572 MKKVKAHALPGVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYTAL 636
            ::::..|:.....:|:||:.|.|||||:|.|.|:|.::|.|||.||||:|:.....||:...|.|
  Rat  1071 IQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYL 1135

  Fly   637 KVQKVGYKVEARGFVKVKG----KGEMETYWLL 665
            .::..|:..:.||.:.|||    :|:::||:||
  Rat  1136 ILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLL 1168

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167
		HNOBA	218..479	CDD:400168	42/215 (20%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	64/196 (33%)
Adcy8	NP_058838.1	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000269|PubMed:16258073, ECO:0000269|PubMed:22494970, ECO:0000269|PubMed:22976297	1..179
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000269|PubMed:22976297	1..106
		Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073	49..51
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..117
		AC_N	<158..397	CDD:292831
		CYCc	363..561	CDD:214485
		Guanylate_cyc	402..586	CDD:278633
		DUF1053	614..708	CDD:283888
		CYCc	941..1145	CDD:214485	63/205 (31%)
		Guanylate_cyc	970..1169	CDD:278633	66/201 (33%)
		Involved in CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073	1106..1248		24/63 (38%)
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000269|PubMed:19305019	1197..1212
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1220..1248

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900