DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Db and Gucy2c

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_037302.1	Gene:	Gucy2c / 25711	RGDID:	2771	Length:	1072	Species:	Rattus norvegicus

Alignment Length:	792	Identity:	180/792 - (22%)
Similarity:	293/792 - (36%)	Gaps:	230/792 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 FKTHQIYPDKLMPD--------------FAAALSAS---TGESFDFCMNFFGRCFVRFFSNFGYD 83
            |..|....|...|:              |.|..|.|   ..|..||.:.:.....:     ||:
  Rat   275 FSNHYFEDDTRAPEYMDNVLVLTLPPEKFIANASVSGRFPSERSDFSLAYLEGTLL-----FGH- 333

  Fly    84 KMIRSTGRYFCDFLQSIDNIHVQMRFTYPKMKSPSMQLT--------NMDDDGAV-----ILYRS 135
             |:::       ||::.:::      |.||.......||        .:||.|.:     :||.|
  Rat   334 -MLQT-------FLENGESV------TTPKFARAFRNLTFQGLEGPVTLDDSGDIDNIMCLLYVS 384

  Fly   136 GRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQ---NDICGGTAGP--------------IKLTE 183
            ..|...|.|:...|...:.........::.::.   ||:.|  .||              :.|..
  Rat   385 LDTRKYKVLMAYDTHKNQTIPVATSPNFIWKNHRLPNDVPG--LGPQILMIAVFTLTGIVVVLLL 447

  Fly   184 GPLTVIVKYRLDFDNRDYMAKRVNVIAHPSQLKMPSVDLNVFLELFPFTIVLDHD---------- 238
            ..|.|:.|||.|.:.|......:     ||:...| ::.|   |....::.:|.|
  Rat   448 IALLVLRKYRRDHELRQKKWSHI-----PSENIFP-LETN---ETNHVSLKIDDDRRRDTIQRVR 503

  Fly   239 ------MKITLAG-----------EKIVETWILHNPGVNPKTFIGS-----------HILERFKC 275
                  .|:.|..           :||....:|.:...|...|.|:           ...||...
  Rat   504 QCKYDKKKVILKDLKHCDGNFSEKQKIELNKLLQSDYYNLTKFYGTVKLDTRIFGVVEYCERGSL 568

  Fly   276 RR--------PKDTQIQWETILQMRTVLFEFELIRTGHNRAAYDAALNFDF------ENFDEASS 326
            |.        |..|.:.||         |:..::.        |.|....:      |......|
  Rat   569 REVLNDTISYPDGTFMDWE---------FKISVLN--------DIAKGMSYLHSSKIEVHGRLKS 616

  Fly   327 LN-EAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATGQRR-----HSVGLRSILLKGQMFY- 384
            .| ...:..:....:|...:.........|:.:.:..||..::     .|:..:.|:|:.:.||
  Rat   617 TNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQATISQKGDVYSFSIIAQEIILRKETFYT 681

  Fly   385 --IKDVDSLIFLCSP-----------LIENLDELHGIGLYLNDLNPHGLSRELVMAGWQH----- 431
              .:|.:..||....           .:|..||.. :.:||           ||.:.|:.
  Rat   682 LSCRDQNEKIFRVENSYGTKPFRPDLFLETADEKE-LEVYL-----------LVKSCWEEDPEKR 734

  Fly   432 ---------CSKLEIMF--EKEEQRSDEL---------------EKSLELADSWKRQGDELLYSM 470
                     .:|:..:|  :|.|...|.|               |:..:|..:.:.:.|.|.:.:
  Rat   735 PDFKKIESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADHLNFML 799

  Fly   471 IPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYDSGSNNI---QDAMQAVTTLNKVFSALDEEI 532
            :||.:.:.:::......:.:|||::.|.:::     |...|   ...|:.|..||.::.:.|:.:
  Rat   800 LPRLVVKSLKEKGIVEPELYEEVTIYFSDIV-----GFTTICKYSTPMEVVDMLNDIYKSFDQIV 859

  Fly   533 ISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLA------LRVMKKVKAHALPG--VAIRVGI 589
            ....||||||:|..|:..||.|..|  ...||.|::      |..|...:...|||  |.||:|:
  Rat   860 DHHDVYKVETIGDAYVVASGLPMRN--GNRHAVDISKMALDILSFMGTFELEHLPGLPVWIRIGV 922

  Fly   590 NSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQKVG--YKVEARGFVK 652
            :|||..|||||:|:||||||||||||||||||:..|..|.:|:.|...:::..  :..|.||...
  Rat   923 HSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTIAILRRTDCQFLYEVRGETY 987

  Fly   653 VKGKGEMETYWL 664
            :||:|...||||
  Rat   988 LKGRGTETTYWL 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	31/154 (20%)
		HNOBA	218..479	CDD:400168	58/363 (16%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	76/190 (40%)
Gucy2c	NP_037302.1	Periplasmic_Binding_Protein_Type_1	34..414	CDD:299141	31/158 (20%)
		PKc_like	479..749	CDD:304357	46/301 (15%)
		STYKc	501..744	CDD:214568	41/271 (15%)
		CYCc	787..978	CDD:214485	70/197 (36%)
		Guanylate_cyc	814..1001	CDD:278633	76/193 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810