DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Db and Gucy1b2

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_011243363.2	Gene:	Gucy1b2 / 239134	MGIID:	2660873	Length:	829	Species:	Mus musculus

Alignment Length:	731	Identity:	193/731 - (26%)
Similarity:	330/731 - (45%)	Gaps:	156/731 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGMLYESVQHYIQQEYGMETWRKV---CQIVDCKHQSFKTHQIYPD----KLMPDFAAALSAST 58
            |||.:...:|..:.:::|.|||.|:   .::.|.    |.|:.:|.|    ||:.:...||..
Mouse   114 MYGFINTCLQSLVTEKFGEETWEKLKASAEVQDV----FMTYTVYDDTITVKLIQEACKALDV-- 172

  Fly    59 GESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPKMKSPSMQLTN 123
              |.:..:..||..|.:|....|||:|:|:.|....:|::::|.:|..:..:|.:|.:||.::..
Mouse   173 --SMEAILKLFGEYFFKFCKMSGYDRMLRTLGGNLTEFIENLDALHSYLALSYQEMNAPSFRVEG 235

  Fly   124 MDDDGAVILYRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLTEGPLTV 188
            ..|....:.|.|.|.|:...:.|.:..|||:|:..|:...:|:...::  ...|  |.......|
Mouse   236 GADGAMRLHYYSDRRGLCHIVPGIIEAVAKDFFDTDVAMSILDMNEEV--ERTG--KKEHVVFLV 296

  Fly   189 IVKYRLDF---------DNRDYMAK-------------------------------RVNVI---- 209
            :.|.|...         |:.:..||                               |.:|:
Mouse   297 VQKARRQIRGAKVNRPRDSENIQAKQESLQGTLLRKKERYLSIPVCPGEKSHSAVVRASVLLGKG 361

  Fly   210 --------AHPSQLKMPSVDLNVFLELFPFTIVLDHDMKITLAGEKIVETWILHNPGVNPKTFIG 266
                    ..|.:|   .::..||...|||.:|.|..:::..||..|.:    :.||:..:.|
Mouse   362 PLGDTFQPVFPERL---WIEEEVFCNAFPFHVVFDEALRVKQAGVNIQK----YVPGILTQKF-- 417

  Fly   267 SHILERFKCRRPKDTQIQWETILQMRTVLFEFELIRTGHNRAAYDAALNFDFENFDEASSLNEAQ 331
             .:.|.|....|:.|                       .|.::....:|..|
Mouse   418 -GLDEYFSIVHPQVT-----------------------FNISSICKFINSQF------------- 445

  Fly   332 AMALASAKEFSAENAKEEAAAAATSKDEIDPATGQRRHSVGLRSILLKGQMFYIKDVDSLIFLCS 396
              .|.:.:|...|..|.:.                        ::.|:|||.:::.:..::|:||
Mouse   446 --ILKTRREMMPEAWKSQP------------------------TLKLRGQMIWMESLKCMVFMCS 484

  Fly   397 PLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLELADSWKR 461
            |.:.:|.||....::|:|:.||..:|:|::...|..:::|:..:.|:::.:....|..||.. |:
Mouse   485 PKLRSLQELEESKMHLSDIAPHDTTRDLILLNQQRLAEMELSCQLEKKKEELRVLSNHLAIE-KK 548

  Fly   462 QGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYDSGSNNIQDA---MQAVTTLNK 523
            :.:.|||:|:|..:|.::::.::.....||..:::|.:|:..     .||..|   :|.|..||.
Mouse   549 KTETLLYAMLPEHVANQLKEGKKVAAGEFETCTILFSDVVTF-----TNICAACEPIQIVNMLNS 608

  Fly   524 VFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLAL--RVMKKVKAHALPG--VA 584
            ::|..|.......||||||:|..||.|.|.|.....||:...:.||  |:..|...:.:.|  :.
Mouse   609 MYSKFDRLTNIHDVYKVETIGDAYMVVGGVPVPVESHAQRVANFALGMRISAKEVMNPVTGEPIQ 673

  Fly   585 IRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQKVGYKVEARG 649
            |||||::|||:|||||.|:||||||||||||||||||...|..:.||......::..|:::..||
Mouse   674 IRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAHRALENKGFEIVTRG 738

  Fly   650 FVKVKGKGEMETYWLL 665
            .::|||||:|.||:|:
Mouse   739 EIEVKGKGKMTTYFLI 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	46/165 (28%)
		HNOBA	218..479	CDD:400168	54/260 (21%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	78/183 (43%)
Gucy1b2	XP_011243363.2	HNOB	115..276	CDD:400167	46/168 (27%)
		HNOBA	380..566	CDD:400168	54/255 (21%)
		Guanylate_cyc	572..754	CDD:306677	78/186 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5138
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.730