DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Db and Gucy1a2

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001028494.1	Gene:	Gucy1a2 / 234889	MGIID:	2660877	Length:	730	Species:	Mus musculus

Alignment Length:	659	Identity:	157/659 - (23%)
Similarity:	296/659 - (44%)	Gaps:	126/659 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LYESVQHYIQQEYGMETWRKVCQIVDCKHQSFKTHQIYPDKLMPDFAAALSAST---GESFDFCM 66
            |..::|:|..|..|.....|....:. |..|:..|....:  :.|.:..|..:.   |..|....
Mouse   107 LKRTLQYYEHQVIGYRDAEKNFHNIS-KRCSYADHSNKEE--IEDVSGILQCTANVLGLQFQEIQ 168

  Fly    67 NFFGRCFVR--FFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPK---MKSPSMQLTNMDD 126
            ..||..|.:  |..|   ::::|:.|....||....|.:...:|.::.|   ::|.|.....:.:
Mouse   169 ERFGEEFFKICFDEN---ERVLRAVGSTLQDFFNGFDALLEHIRTSFGKQATLESSSFLCKELPE 230

  Fly   127 DGAVILYRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLTEGPLTVIVK 191
            ...::.|......:...::|.:....|..|.|::....:|::. :|...:.|...:  .||.::|
Mouse   231 GTLMLHYFHPHHTVGFAMLGMIKAAGKRIYHLNVEVEQIENEK-LCFDGSNPSNCS--CLTFLIK 292

  Fly   192 ----YRLDFDNRDYMAKRVNVIAHPSQLKMPSVDLNVFLELFPFTIVLDHDMKITLAGEKIVETW 252
                .::..||....::      .|:.|:   :.:|.|...|||.::.|.:|.:...||.:.:
Mouse   293 ECETTQITKDNPQGTSQ------VPADLR---ISINTFCRAFPFHLMFDSNMVVLQLGEGLRK-- 346

  Fly   253 ILHNPGVNPKTFIGSHILERFKCRRPKDTQIQWETILQMRTVLFE--FELIRTGHNRAAYDAALN 315
                                         |::::|   .|.:.||  ||::....| |.:|..|
Mouse   347 -----------------------------QLRYDT---HRALKFEDCFEIVSPMIN-ATFDRVL- 377

  Fly   316 FDFENFDEASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATGQRRHSVGLRSILLKG 380
                               |..:..|......|  |:...::|::               :.:||
Mouse   378 -------------------LRLSTPFVIRTKPE--ASGTENEDKV---------------MEIKG 406

  Fly   381 QMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQR 445
            ||.::.:..:::||.||.::.||||.|.||:|:|:..|..:|::::.|.|  :|.:...:|   |
Mouse   407 QMIHVPESSAILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQ--AKAQDGLKK---R 466

  Fly   446 SDELEKSLE----LADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYDS 506
            .|:|:.:||    ..:..|::..:||||:.|..:|:::.:.::...:.|::|:::|.:::
Mouse   467 MDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIV----- 526

  Fly   507 GSNNI---QDAMQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLA 568
            |...|   ...||.::.||::::..|.:.....:|||||:|..|...||....:..||:....:|
Mouse   527 GFTAICAQCTPMQVISMLNELYTRFDHQCGLLDIYKVETIGDAYCVASGLHRKSLCHAKPIALMA 591

  Fly   569 LRVMKKVKAHALP---GVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQL 630
            |::|:..:....|   .:.:|:||:||.|:|||||:::|||||||:.|..||:.||.|.|..|.:
Mouse   592 LKMMELSEEVLTPDGKAIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINV 656

  Fly   631 S--NYTALK 637
            |  .|..||
Mouse   657 SPTTYQLLK 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	32/163 (20%)
		HNOBA	218..479	CDD:400168	60/266 (23%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	55/158 (35%)
Gucy1a2	NP_001028494.1	HNOB	<157..268	CDD:285002	21/113 (19%)
		HNOBA	314..501	CDD:285003	60/266 (23%)
		CYCc	483..672	CDD:214485	62/188 (33%)
		Guanylate_cyc	512..696	CDD:278633	55/159 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820