DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Db and PHLPP2

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_055835.2	Gene:	PHLPP2 / 23035	HGNCID:	29149	Length:	1323	Species:	Homo sapiens

Alignment Length:	553	Identity:	95/553 - (17%)
Similarity:	172/553 - (31%)	Gaps:	186/553 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 FFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPKM--------KSPSMQLTNMDDDGAVIL 132
            :.|..|:|                 |.:.:|...|.|.:        :.|    .:||....::|
Human   110 YLSRLGFD-----------------DPVRIQEEATNPDLGCMIRFYGEKP----CHMDRLDRILL 153

  Fly   133 -----YRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLTEGPLTVIVK- 191
                 .|.|:|.:.|:        |:....|..|..::.|..|...|....:.|..|.:..:.:
Human   154 SGIYNVRKGKTQLHKW--------AERLVVLCGTCLIVSSVKDCQTGKMHILPLVGGKIEEVKRR 210

  Fly   192 -YRLDFDNRDYMAKRVNVIAHP---------------SQLKMPSVDLNVF-LELFPFTIVLDHDM 239
             |.|.|.:....|:..:|....               || ::.:|||:.: ||..|..:....|:
Human   211 QYSLAFSSAGAQAQTYHVSFETLAEYQRWQRQASKVVSQ-RISTVDLSCYSLEEVPEHLFYSQDI 274

  Fly   240 KITLAGEKIVETWILHNPGVNPKTFIGSHILERF------------------------------- 273
            .........::   |..||       |...|.:|
Human   275 TYLNLRHNFMQ---LERPG-------GLDTLYKFSQLKGLNLSHNKLGLFPILLCEISTLTELNL 329

  Fly   274 KCRRPKDTQIQWETILQMRTVLFEFELIRT-----GHNRAAYDAALNFDFENFDEASSLNEAQAM 333
            .|....|...|...:|.::|:..:...:.|     |:.:..  ::|...|.||.:...:.|...|
Human   330 SCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQL--SSLGISFNNFSQIPEVYEKLTM 392

  Fly   334 ALASAKEFSAENAKEEAAAAATSKDEIDPATGQRRHSVGLRSILLKGQMFYIKDVD-SLIFLCSP 397
            .   .:...|.|..|                        :.::.:..:|.:||.|| .:..|.:.
Human   393 L---DRVVMAGNCLE------------------------VLNLGVLNRMNHIKHVDLRMNHLKTM 430

  Fly   398 LIENLD---ELHGIGLYLNDLNPHGLS---------------RELVMAGWQHCSKLEIMFEKEEQ 444
            :||||:   .:..:.|..|.|....||               |||.::|:    .|..::....:
Human   431 VIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGF----SLRTLYASSNR 491

  Fly   445 RS--------------DELEKSLELADSWKRQGDEL--------LYSMIPRPIAE--RMRK---S 482
            .:              |.....||....|..:..::        |.:.:|..|..  .:||   .
Human   492 LTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLG 556

  Fly   483 EEHVCQSFEEVSVIFIEVMNIYDSGSNNIQDAM 515
            ..||......|..|.:||:::..:....:.|.:
Human   557 HNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTL 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	17/97 (18%)
		HNOBA	218..479	CDD:400168	56/340 (16%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	5/28 (18%)
PHLPP2	NP_055835.2	PH_PHLPP-like	149..243	CDD:270131	18/101 (18%)
		LRR 1	250..271		6/20 (30%)
		leucine-rich repeat	253..273	CDD:275380	6/19 (32%)
		LRR 2	273..296		5/32 (16%)
		leucine-rich repeat	274..300	CDD:275380	6/35 (17%)
		LRR 3	300..321		0/20 (0%)
		leucine-rich repeat	301..323	CDD:275380	0/21 (0%)
		LRR_RI	313..606	CDD:238064	52/310 (17%)
		LRR_8	322..380	CDD:290566	9/59 (15%)
		LRR 4	323..344		3/20 (15%)
		leucine-rich repeat	324..346	CDD:275380	3/21 (14%)
		LRR 5	346..368		3/21 (14%)
		leucine-rich repeat	347..369	CDD:275380	3/21 (14%)
		LRR 6	369..390		5/22 (23%)
		leucine-rich repeat	370..416	CDD:275380	10/74 (14%)
		LRR 7	392..412		4/46 (9%)
		LRR 8	416..439		9/22 (41%)
		leucine-rich repeat	418..440	CDD:275380	8/21 (38%)
		LRR 9	440..460		5/19 (26%)
		leucine-rich repeat	442..461	CDD:275380	5/18 (28%)
		LRR 10	461..480		3/18 (17%)
		leucine-rich repeat	462..481	CDD:275380	4/22 (18%)
		LRR 11	481..502		1/20 (5%)
		leucine-rich repeat	482..503	CDD:275380	1/20 (5%)
		LRR 12	503..524		4/20 (20%)
		leucine-rich repeat	504..526	CDD:275380	4/21 (19%)
		LRR 13	526..547		3/20 (15%)
		leucine-rich repeat	527..549	CDD:275380	3/21 (14%)
		LRR_8	549..606	CDD:290566	9/41 (22%)
		LRR 14	549..570		5/20 (25%)
		leucine-rich repeat	550..565	CDD:275380	4/14 (29%)
		LRR 15	571..592		3/19 (16%)
		leucine-rich repeat	572..595	CDD:275380	3/18 (17%)
		LRR 16	595..616
		leucine-rich repeat	596..645	CDD:275380
		LRR 17	621..644
		LRR_8	645..703	CDD:290566
		LRR_4	645..685	CDD:289563
		LRR 18	645..666
		leucine-rich repeat	646..669	CDD:275380
		LRR 19	669..690
		leucine-rich repeat	670..692	CDD:275380
		LRR 20	692..713
		leucine-rich repeat	693..714	CDD:275380
		LRR 21	714..735
		leucine-rich repeat	715..734	CDD:275380
		LRR 22	737..758
		leucine-rich repeat	738..764	CDD:275380
		PP2Cc	784..1033	CDD:238083
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1060..1157
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1285..1323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900