DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Db and Adcy5

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001012783.3	Gene:	Adcy5 / 224129	MGIID:	99673	Length:	1262	Species:	Mus musculus

Alignment Length:	320	Identity:	100/320 - (31%)
Similarity:	166/320 - (51%)	Gaps:	64/320 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   404 ELHGIGLYLN----------DLNPHGLSR-------------------ELVMAGWQHCSKLE--- 436
            |:.|:.|:.|          |.:.:|.|:                   ..|:|.:.|..::|
Mouse   949 EVPGVTLFDNADLLVTANAIDFSNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTA 1013

  Fly   437 -IMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIA----ERMRKSEEHVCQSFEEVSVI 496
             :.|..:.|.::|.|:..|| .::.|:   ||::::|:.:|    .|.|:::|...||.|.|:|:
Mouse  1014 RLDFLWKLQATEEKEEMEEL-QAYNRR---LLHNILPKDVAAHFLARERRNDELYYQSCECVAVM 1074

  Fly   497 FIEVMNI----YDSGSNNIQDAMQAVTTLNKVFSALDEEIISPFVY----KVETVGMVYMAVSGA 553
            |..:.|.    .:..:||  :.::.:..||::.:..| ||||...:    |::|:|..|||.||.
Mouse  1075 FASIANFSEFYVELEANN--EGVECLRLLNEIIADFD-EIISEDRFRQLEKIKTIGSTYMAASGL 1136

  Fly   554 PD-----VNPLHAEHACDLALRV---MKKVKAHALPGVAIRVGINSGPVVAGVVGMKVPRYCLFG 610
            .|     ....|.:...|.|:::   ||.:..|:.....:::|:|.|||||||:|.:.|:|.::|
Mouse  1137 NDSTYDKAGKTHIKAIADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWG 1201

  Fly   611 DTVNTASRMESSSDPWMIQLSN--YTALKVQKVGYKVEARGFVKVKGKGEMETYWLLEGP 668
            :|||.||||:|:..|..||::.  |..|....  |::|.||.|||||||||.||:|..||
Mouse  1202 NTVNVASRMDSTGVPDRIQVTTDMYQVLAANT--YQLECRGVVKVKGKGEMMTYFLNGGP 1259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167
		HNOBA	218..479	CDD:400168	22/111 (20%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	72/194 (37%)
Adcy5	NP_001012783.3	AC_N	1..459	CDD:292831
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..194
		CYCc	425..620	CDD:214485
		Guanylate_cyc	461..622	CDD:278633
		DUF1053	669..761	CDD:283888
		CYCc	1037..1238	CDD:214485	66/208 (32%)
		Guanylate_cyc	1063..1257	CDD:278633	73/198 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810