DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Db and Adcy2

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_705762.2	Gene:	Adcy2 / 210044	MGIID:	99676	Length:	1095	Species:	Mus musculus

Alignment Length:	325	Identity:	90/325 - (27%)
Similarity:	162/325 - (49%)	Gaps:	50/325 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   371 VGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQ---HC 432
            ||...|||......:.....::|....:.::|..:..:.|.:..:.       |::.|.|   :|
Mouse   775 VGYNIILLHTHAHVLDAYSQVLFQRPGIWKDLKTMGSVSLSIFFIT-------LLVLGRQSEYYC 832

  Fly   433 SKLEIM----FEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAE----RMRKSEEHVCQS 489
             :|:.:    |:||.:..:.:|....:          ||.:::|..:||    |..|:||...||
Mouse   833 -RLDFLWKNKFKKEREEIETMENLNRV----------LLENVLPAHVAEHFLARSLKNEELYHQS 886

  Fly   490 FEEVSVIFIEV---MNIYDSGSNNIQDAMQAVTTLNKVFSALDEEIISP---FVYKVETVGMVYM 548
            ::.|.|:|..:   ...|.....| ::.::.:..||::.:..|:.:..|   .|.|::|:|..||
Mouse   887 YDCVCVMFASIPDFKEFYTESDVN-KEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYM 950

  Fly   549 AVSG-----------APDVNPLHAEHACDLALRVMKKVKA---HALPGVAIRVGINSGPVVAGVV 599
            |.:|           .|:...:|.....:.|..::.|:.|   |:.....:|||||.|||:|||:
Mouse   951 AATGLSAVPSQEHAQEPERQYMHIGTMVEFAYALVGKLDAINKHSFNDFKLRVGINHGPVIAGVI 1015

  Fly   600 GMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQKVGYKVEARGFVKVKGKGEMETYWL 664
            |.:.|:|.::|:|||.||||:|:.....||::..|:|.:|.:||....||.:.|||||:::||::
Mouse  1016 GAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGDLKTYFV 1080

Fly 665 664
Mouse 1081 1080

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167
		HNOBA	218..479	CDD:400168	22/118 (19%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	64/197 (32%)
Adcy2	NP_705762.2	AC_N	<37..264	CDD:292831
		CYCc	240..443	CDD:214485
		Guanylate_cyc	285..469	CDD:278633
		DUF1053	499..603	CDD:283888
		CYCc	852..1060	CDD:214485	64/218 (29%)
		Guanylate_cyc	882..1081	CDD:278633	64/200 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810