DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Db and ADCY4

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001185497.1	Gene:	ADCY4 / 196883	HGNCID:	235	Length:	1077	Species:	Homo sapiens

Alignment Length:	334	Identity:	100/334 - (29%)
Similarity:	170/334 - (50%)	Gaps:	63/334 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   383 FYIKDVDSLIFL---CSPLIEN---LDELHGIGLYLNDLNPH-GLSRE----------------L 424
            |.:|.:..|::|   ||..:.:   |.|...:.|||..|:.. |:.:|                |
Human   740 FELKLLLLLLWLAASCSLFLHSHAWLSECLIVRLYLGPLDSRPGVLKEPKLMGAISFFIFFFTLL 804

  Fly   425 VMAGW-QHCSKLEIMFEK----EEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERM----R 480
            |:|.. ::..:|:.:::|    |.:.::.:|....|          ||.:::|..:|.:.    |
Human   805 VLARQNEYYCRLDFLWKKKLRQEREETETMENLTRL----------LLENVLPAHVAPQFIGQNR 859

  Fly   481 KSEEHVCQSFEEVSVIFIEVMNI--YDSGSNNIQDAMQAVTTLNKVFSALDEEIISP---FVYKV 540
            ::|:...||:|.|.|:|..|.:.  :.|.||...:.::.:..||::.:..||.:..|   .|.|:
Human   860 RNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKI 924

  Fly   541 ETVGMVYMAVSG-----APDVNPLHAEHAC-------DLALRVMKK---VKAHALPGVAIRVGIN 590
            :|:|..|||.:|     ..|... .||.:|       :.|:.:..|   :..|:.....:|||:|
Human   925 KTIGSTYMAATGLNATSGQDAQQ-DAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLN 988

  Fly   591 SGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQKVGYKVEARGFVKVKG 655
            .|||||||:|.:.|:|.::|:|||.||||||:.....||::..||..:|.:||...:||.:||||
Human   989 HGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYTCYSRGVIKVKG 1053

  Fly   656 KGEMETYWL 664
            ||::.||:|
Human  1054 KGQLCTYFL 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167
		HNOBA	218..479	CDD:400168	26/123 (21%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	72/197 (37%)
ADCY4	NP_001185497.1	AC_N	<115..246	CDD:292831
		CYCc	219..422	CDD:214485
		Guanylate_cyc	264..418	CDD:278633
		DUF1053	479..583	CDD:283888
		CYCc	827..1042	CDD:214485	69/225 (31%)
		Guanylate_cyc	864..1063	CDD:278633	72/200 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810