DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Db and gcy-36

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_510557.3	Gene:	gcy-36 / 191657	WormBaseID:	WBGene00001556	Length:	675	Species:	Caenorhabditis elegans

Alignment Length:	696	Identity:	197/696 - (28%)
Similarity:	324/696 - (46%)	Gaps:	103/696 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGMLYESVQHYIQQEYGMETWRKVCQIV--DCKHQSFKTHQIYPDKLMPDFAAALSASTGESFD 63
            |:|.::||::..:.:.||...|.||.:..  :...::...| .|.|........|:|.....:.:
Worm     1 MFGFIHESIRQLMIRTYGEAFWSKVLERAGFEAGKENIINH-YYSDADTFSLVDAVSVILKVTRE 64

  Fly    64 FCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPK--MKSPSMQLTNMDD 126
            .....:|...:::....|:|.:|||.......||.::|::|..:.....|  ::.||.:..:..|
Worm    65 QVWEMYGCFLIQYTMETGWDDLIRSMSPNLKGFLDNLDSLHYFIDHVVYKANLRGPSFRCEDNPD 129

  Fly   127 DGAVILYRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLTEGP-----L 186
            ....:.|.:||.|:...:.|.:.|.||..:.||::.       .|.|.|...:::..|.     :
Worm   130 GTITLHYYTGRPGLYPIVKGVLREAAKRVFKLDVSM-------TITGRTQRSVQMATGERIEEHV 187

  Fly   187 TVIVKYRLDFDNRDYMAKRVNVIAHPSQLKMPSVDLNVFLELFPFTIVLDHDMKITLAGEKIVET 251
            ..:|| .|:.|..:..|....|:.|.:..|:....:: |:..||:.:|:|.|.||...|.:
Worm   188 IFLVK-TLNTDQSNEEALGTAVVQHSNNYKIRLTHMD-FISTFPYHMVVDQDCKIVQVGRE---- 246

  Fly   252 WILHNPGVNPKTFIGSHILERFKCRRPKDTQIQWETI---------LQMRTVLFEFELIRTGHNR 307
              |:|........:|:.::..|:..||: ..:.:::|         ||::|...||:  |..:.|
Worm   247 --LYNHIPKDLLSVGTPLMRIFEVTRPQ-IPLDFDSICNFINAVFVLQVKTTPMEFQ--RNANKR 306

  Fly   308 AAYDAALNFDFENFDEASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATGQRRHSVG 372
            |                     |||:.       ::||..|:...|.        |..|.:|
Worm   307 A---------------------AQAIE-------ASENLYEDNNGAL--------ALSQSQH--- 332

  Fly   373 LRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLE- 436
               :.|||||..:.....:::||||.:.::.||...||.|..:..|..:|:|::...|..|.:|
Worm   333 ---LKLKGQMMLMSSGGHIMYLCSPYVTSIPELLQYGLRLTAMPIHDPTRDLILLNQQRLSDVEM 394

  Fly   437 -IMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEV 500
             :..|...::.:.:.|.||:.   |.:.|.||..|:|..:|:::::......:.:||.:|:|.:|
Worm   395 NLQLEANNEQLENMAKDLEVE---KGKTDALLREMLPPSVAQQLKQGLSVEAREYEEATVMFTDV 456

  Fly   501 MNIYDSGSNNIQDAMQAVT------TLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPL 559
                    ...|..:...|      .||::|:..|..|.....|||||||..||:|.|.||:...
Worm   457 --------PTFQQIVPLCTPKDIVHLLNELFTKFDRLIGIQKAYKVETVGDSYMSVGGIPDLVDD 513

  Fly   560 HAEHACDLALRVMKKVKAHALP----GVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRME 620
            |.|..|.|||.::.:.:....|    .:.||.||:||||||||||.|:||||||||||||:||||
Worm   514 HCEVICHLALGMVMEARTVCDPITNTPLHIRAGIHSGPVVAGVVGAKMPRYCLFGDTVNTSSRME 578

  Fly   621 SSSDPWMIQLSNYTALKVQKVG-YKVEARGFVKVKGKGEMETYWLL 665
            |.|....|..|.......:..| ::.|.||.|::||||||.||:||
Worm   579 SHSPIGRIHCSENAKKCAESTGRFEFEPRGRVQIKGKGEMNTYFLL 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	37/162 (23%)
		HNOBA	218..479	CDD:400168	65/271 (24%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	80/187 (43%)
gcy-36	NP_510557.3	HNOB	3..167	CDD:285002	37/171 (22%)
		HNOBA	217..435	CDD:285003	65/272 (24%)
		CYCc	415..604	CDD:214485	75/199 (38%)
		Guanylate_cyc	441..624	CDD:278633	80/190 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.780