DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Db and gcy-34

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_506319.1	Gene:	gcy-34 / 191656	WormBaseID:	WBGene00001554	Length:	686	Species:	Caenorhabditis elegans

Alignment Length:	702	Identity:	182/702 - (25%)
Similarity:	318/702 - (45%)	Gaps:	110/702 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGMLYESVQHYIQQEYGMETWRKVCQIVDCKHQSFK------THQIYPDK----LMPDFAAALS 55
            |:|.::||::..:.::||.:.|.:|.:     ...|:      .:..|.|.    |:...:..|.
Worm     1 MFGFIHESIRQLVIRKYGEDVWLQVLE-----RSGFENGKENIVNHYYSDTDTYVLVDSVSIVLK 60

  Fly    56 ASTGESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPK--MKSPS 118
            .:..:.::    .:|...:.:....|:|:::||.......||.::|::|..:.....|  ::.||
Worm    61 VTKDQIWE----MYGGFLITYSMEIGWDELVRSMSPNLKGFLDNLDSLHYFIDHVVYKANLRGPS 121

  Fly   119 MQLTNMDDDGAVILYRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLTE 183
            .:.....|...::.|.:||.|:...:.|.:.||||..:.||::..|.       |.|...:.:..
Worm   122 FRCEENPDGTLMLHYFTGRPGLYHIVKGVVKEVAKLVFNLDISLVVQ-------GRTQRSVHMNN 179

  Fly   184 GP-----LTVIVKYRLDFDNRDYMAKRVNVIAH---------PSQLKMPSVDLNVFLELFPFTIV 234
            |.     :..::| .::...||......:.:..         ...||   |.|..|....|:..|
Worm   180 GERVEEHVIFLIK-NVEEPRRDSDTSTTSALTSVEPDFGEIIDDNLK---VSLQDFSRALPYHFV 240

  Fly   235 LDHDMKITLAGEKIVETWILHNPGVNPKTFIGSHILERFKCRRPKDTQIQWETILQMRTVLFEFE 299
            ||...::...|::      |:|...|.....|:.||..|:..||:
Worm   241 LDESCRLVQCGDE------LYNHIPNELLQPGTPILRIFEINRPQ-------------------- 279

  Fly   300 LIRTGHNRAAYDAALNFDFE---NFDEASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEID 361
                          :..|||   ||..|..:.:.:...|.. |..:|...:|........::|::
Worm   280 --------------IPLDFENICNFINAVFVLQVKTSPLRK-KHMNAMTKEEREQEVEAMEEEVE 329

  Fly   362 PATGQRRHSVGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVM 426
              :.:......|:   |||||..:.....:|:||||.:.:::||...|:.|..:..|..:|:|::
Worm   330 --SNELTQGCHLK---LKGQMMMLSTKKHIIYLCSPYVTSINELMQFGMRLTAMPLHDATRDLIL 389

  Fly   427 AGWQHCSKLEIMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFE 491
            ...|..|.:|:..:. |..:::||......:..:::.|.:|..|:||.||::: .|.||:.....
Worm   390 LNQQRLSDVEVNLQL-EANNEQLETMTHELEVERQKTDSILKDMLPRKIAKQL-LSGEHLEPCEY 452

  Fly   492 EVSVIFIEVMNIYDSGSNNIQDAMQ---AVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGA 553
            |.:|:|.::     .....|....|   .|..||:||..||..::...|||||||...||.|||.
Worm   453 EATVMFCDL-----PAFQQIIPVCQPKNIVKLLNEVFFKLDRIVVLRGVYKVETVSDSYMTVSGI 512

  Fly   554 PDVNPLHAEHACDLALRVMKKVKAHALP----GVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVN 614
            ||....|||:.|.:||.:|.:.::...|    ...:|:|::||.::|||||.|:|||||||:||.
Worm   513 PDYTSEHAENMCHVALGMMWEARSVMDPVNKTPFLLRIGLHSGTIIAGVVGTKMPRYCLFGETVT 577

  Fly   615 TASRMESSSDPWMIQLSNYTALKVQKVG-YKVEARGFVKVKGKGEMETYWLL 665
            .||:|||......||.|::|..|..:.| ::...||.:.|||:|::|||:|:
Worm   578 LASQMESLGVAGKIQCSSWTYSKAMETGRFEFSPRGRINVKGRGDVETYFLM 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	36/170 (21%)
		HNOBA	218..479	CDD:400168	59/263 (22%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	73/184 (40%)
gcy-34	NP_506319.1	HNOB	3..167	CDD:285002	36/172 (21%)
		HNOBA	224..441	CDD:285003	61/266 (23%)
		CYCc	421..609	CDD:214485	74/193 (38%)
		Guanylate_cyc	453..629	CDD:278633	73/180 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.780