DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Db and gcy-31

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001024889.1	Gene:	gcy-31 / 191655	WormBaseID:	WBGene00001551	Length:	702	Species:	Caenorhabditis elegans

Alignment Length:	703	Identity:	194/703 - (27%)
Similarity:	345/703 - (49%)	Gaps:	121/703 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGMLYESVQHYIQQEYGMETWRKVCQIVDCKHQSFKTHQIYPDKLMPDFAAALSASTGESFDFC 65
            |||::.:.:..||:::||..||.:|..:......:|:..:.:.:.|......|....||:..|..
Worm     1 MYGLIIDHIATYIKEKYGESTWSEVKFVSGVTDDTFQMDKKFSEGLSHKLIWACHDVTGDPVDEL 65

  Fly    66 MNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPKMKSPSMQLTNMDDDGAV 130
            |...|..|.:|.:.|.::|::|..||.|..||..:||:|..:|||:||:|.||....:....|..
Worm    66 MTNIGTSFYKFLTKFEFNKVLRVLGRTFPQFLNGLDNLHEYLRFTFPKLKPPSFYCEHESRTGLT 130

  Fly   131 ILYRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLTEGPLTVIVKYRLD 195
            :.|||.|.|...|:.||:..:::|.:..::...:|:.::|        :.|..      |..||.
Worm   131 LHYRSKRRGFLHYVQGQIRNISQELFQTEVVIELLDIEHD--------LNLEH------VIMRLH 181

  Fly   196 FDNRDYMAKRV---NVIAHPSQLKMPSVDLNVFLELFPFTIVLDHDMKIT------------LAG 245
            |:|.|:..:..   |:  :.|.|:...:..::|.::|||.||.:..|:|.            :.|
Worm   182 FNNLDFNRQGTAYRNL--NDSILEKVKITSDIFFDIFPFIIVFNRGMRIRNIGIGLLRVMAGIVG 244

  Fly   246 EKIVETWILHNPGVNPKTFIGSHILERFKCRRPKDTQIQWETILQMRTVLFEFELIRTGHNRAAY 310
            :||.:|::|..|      ||      ||:          ||.|:.....:||.
Worm   245 KKINQTFLLMRP------FI------RFR----------WEEIMLHSNNIFEL------------ 275

  Fly   311 DAALNFDFENFDEASSLNEAQAMALASAKEFSAENAKEEAAAAATSK-DEIDPATGQRRHSVG-- 372
                                          .|::..:|:.......| .::|..| :.||.:|
Worm   276 ------------------------------ISSDPIQEDEDGILVYKTTDVDQMT-EERHRMGDG 309

  Fly   373 --LRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKL 435
              .:.:.|||||||:::.:|:.|:..|::.:|.:::..||::||...|..||:||:|..|..::|
Worm   310 EREKFLSLKGQMFYMEEWESICFVGIPVMSHLPQMYKSGLFINDFALHDSSRDLVLASTQQSAEL 374

  Fly   436 EIMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHV--CQSFEEVSVIFI 498
            :::..:|.|:|..:.:::......:|:.|:|||.|:|:.:|.::|..|..|  |:.|:.|:::|.
Worm   375 KLLLHQEAQKSRNMRENMNRLKKERRRTDKLLYQMLPKSVANQLRHGESAVACCERFDSVTILFT 439

  Fly   499 EVMNIYDSGSNNIQDAMQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEH 563
            :::......|:  ...::.:..|..:::..|:.|.:..||||||:|..||.|||||......||.
Worm   440 DIVEFTKMCSS--LTPLEVIEFLKVIYTNFDKIIDTHGVYKVETIGDAYMVVSGAPTKTEHDAEF 502

  Fly   564 ACDLALRVMKKV--------KAHALPGVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRME 620
            ..|.|.:.:.:.        |.|.   :.||.|::||.|||||||:.:|||||||:||..|::||
Worm   503 ILDCASQFLVEAGKMVNMNNKIHK---IDIRAGVHSGSVVAGVVGLSMPRYCLFGETVYVANKME 564

  Fly   621 SSSDPWMIQLSNYTALKVQKVG---YKVEARGFVKVKGKGEMETYWLL--EGP 668
            .:|.|..|.:|..|..|:::..   |:.|.|..:::|....::|::::  .||
Worm   565 QNSSPMKILVSETTHNKIEESDPGLYQFERREEIEIKDDQTIQTFFVVSRHGP 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	48/158 (30%)
		HNOBA	218..479	CDD:400168	65/277 (23%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	62/187 (33%)
gcy-31	NP_001024889.1	HNOB	2..164	CDD:285002	48/161 (30%)
		HNOBA	221..418	CDD:285003	60/261 (23%)
		CYCc	397..592	CDD:214485	70/199 (35%)
		Guanylate_cyc	429..613	CDD:278633	62/188 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46420
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.930