DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Db and gcy-23

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_500309.3	Gene:	gcy-23 / 191652	WormBaseID:	WBGene00001548	Length:	1073	Species:	Caenorhabditis elegans

Alignment Length:	754	Identity:	174/754 - (23%)
Similarity:	299/754 - (39%)	Gaps:	201/754 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ETWRKVCQ-----IVDCKHQSFKT----HQIYPDKLMPDFAAALSAS----------TGESFDFC 65
            :|.||||:     :.:|  ...||    :::....|...|..::..|          ..|..|:.
Worm   395 DTVRKVCELEPVMLTNC--DGTKTGNGCYELQVTDLSTGFWPSIDGSLPADEPACGFRNEKCDYT 457

  Fly    66 MNFFGRCFVR--------FF--SNFGYDKMIRST-GRYFCDFLQSIDNIHVQMRFTYPKMKSPSM 119
            ....|.|.|.        ||  |....::.:.:| .|.:.|..::|....::...:....|:...
Worm   458 TLIIGGCIVLLIILLIICFFILSRVCENRALANTPWRIYRDDFRTIQENEMKSMLSIGSSKTKMS 522

  Fly   120 QLTNMDDDGAVI---------LYRSGR----TGMSKYLIGQMTEVAKE----FYGLDMTAYVLES 167
            .::......||:         ||...|    ......|:.||.:...:    |.|:...    |.
Worm   523 NMSMFVKHHAVVGTNTHASFHLYPQRRPIVFNRQDLQLLNQMKQAVHDNLNPFLGMSFN----EK 583

  Fly   168 QNDI-----CGGTAGPIKLTEGPLTVIVKYRLDFDNRDYMAKRVNVIAHPSQLKMPSVDLNVFLE 227
            :..:     |  :.|.|:      .:|....:..|::          .|.:.::    |:.:.||
Worm   584 EEMVVLWKFC--SRGTIQ------DMIYNQEVSLDSK----------FHGAFIR----DITLGLE 626

  Fly   228 ------------LFPFTIVLDHDMKITLAGEKIVETWILHNPGVNPKTFIGSHILERFKCRRPKD 280
                        |.|::.::|.:..|.|....|          .||        |||
Worm   627 YLHSSIIGYHGSLTPWSCLIDRNWMIKLTDYGI----------ANP--------LER-------- 665

  Fly   281 TQIQWETILQMRTVLFEFELIRTGHNR--AAYDAALNFDFENFDEASSLNEAQAMALASAKEFSA 343
                ||     :..|...|.::.|.::  :|...:|.:......:....|..:.|..:..|:..|
Worm   666 ----WE-----KLGLISTETLKEGDDKSGSAQKTSLLYQPPEMLKNKESNRTRRMDQSWVKQSQA 721

  Fly   344 ENAKEEAAAAATSKDEIDPATGQRRHSVGLRSI------LLKGQMFYIKDVDSLIFLCSPLIENL 402
            .....:..           |.|...|.:..|::      .:...|.||:|.....   .|.:.:.
Worm   722 RRQMGDIY-----------AFGMVMHEILFRALPFPNGTNVSEVMDYIRDGTKTF---RPTVHDR 772

  Fly   403 DELHG--IGLYLN--DLNPH--------GLSRE--LVMAGWQHCSKLEIMFEKEEQRSDELEK-- 451
            .::|.  :.|.|:  :.||.        .|:.|  |.:.|    |.::.|....||.::.|||
Worm   773 TQIHPDLVALLLDCWNENPEVRPSIRRVRLNTENYLKVKG----SLVDQMMRMMEQYANNLEKLV 833

  Fly   452 -----SLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYDSGSNNI 511
                 .||.|:.   :.|:||..::|:.:|..::.......::|:..:|:|.:::......|::
Worm   834 AERTGMLEEANV---RADKLLGQLLPKYVANELKMGRSVPAKTFDMATVMFSDIVGFTTICSSS- 894

  Fly   512 QDAMQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVN-PLHAEHACDLALRVMKKV 575
             ..::.|:.||.::|..|:.|.....|||||:|..||.|||.|:.| ..|..:.|:.||.:|..:
Worm   895 -TPLEVVSMLNSIYSKFDDAINKHGSYKVETIGDAYMIVSGIPEENGNEHIRNICNTALELMLLL 958

  Fly   576 KAHALP-----GVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSN--- 632
            |.:.:|     .:.||:||::|.|.|||||:..|||||||||||.||||||:|:|..||:|.
Worm   959 KTYEIPHRRNVKLRIRLGIHTGTVAAGVVGLTAPRYCLFGDTVNVASRMESTSEPEKIQMSQEAR 1023

  Fly   633 ------YTALKVQKVGYKVEARGFVKVKGKGEMETYWLL 665
                  |:.       :::..||.|:.||||.:.:||||
Worm  1024 DFCVRYYSE-------FQITLRGTVEAKGKGPVTSYWLL 1055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	34/187 (18%)
		HNOBA	218..479	CDD:400168	58/301 (19%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	73/191 (38%)
gcy-23	NP_500309.3	Periplasmic_Binding_Protein_Type_1	38..407	CDD:299141	5/11 (45%)
		ANF_receptor	38..385	CDD:279440
		PK_GC	509..806	CDD:270894	58/371 (16%)
		HNOBA	<817..863	CDD:285003	14/48 (29%)
		CYCc	842..1035	CDD:214485	70/204 (34%)
		Guanylate_cyc	869..1056	CDD:278633	75/196 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810