DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Db and gcy-1

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_496039.1	Gene:	gcy-1 / 191639	WormBaseID:	WBGene00001528	Length:	1137	Species:	Caenorhabditis elegans

Alignment Length:	696	Identity:	178/696 - (25%)
Similarity:	281/696 - (40%)	Gaps:	201/696 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 FTYP-KMKSPSMQLTNMDDDGAVILYRSGRTGMSKYLIGQMTEVAKEFYG----LDMTAYVLESQ 168
            |||. .:..|::.|...|:.|||..|                      ||    ||:
Worm   441 FTYTNSVMVPNVTLFYKDEGGAVWSY----------------------YGHSRPLDI-------- 475

  Fly   169 NDICG--GTAGPIKLTE----------------------GPLTVIVKYRLDFD--NRDYMAKRVN 207
             .|||  |.:.|:...|                      |.|.||...|.:..  |.::......
Worm   476 -PICGFLGKSCPVSFWEQYKILIFVAIAVIVLMVLIMIIGCLCVISGKRAERARINAEWQVPFAK 539

  Fly   208 VIAHPSQLK-----------MPSVD--------LNVFLELFPFTIVLDHDMKITLA--------- 244
            :|....|::           .||:.        ::.|.|.:.. ::.:.:|.:|..
Worm   540 LIESEKQVRGKGASRRSLQSAPSISTGHSGVTTVSDFCENYTM-MMYEKEMVLTAKYQYTHLTKA 603

  Fly   245 -GEKIVETWILHNPGVNPKTFIG-----SHILERFK-CRRPKDTQIQWETILQMRTVLFEFELIR 302
             .|:.|:...|.:..:|  .|||     :|.:...| |.|.....|.......| ...|.|.:||
Worm   604 DKERFVKMRKLDHENIN--RFIGLSIDSAHFISVTKLCSRGSLQDILSRGNFSM-DYFFMFCIIR 665

  Fly   303 TGHNRAAYDAALNFDF---------ENFDEASSL-NEAQAMALASAKEFSAENAKE--------- 348
                    |.|...::         .|...|:.| |::..:.||   |:..:|..|
Worm   666 --------DVAKGLEYLHKTFLRLHGNLRSATCLVNDSWQVKLA---EYGMDNLVEEQTPPKKRL 719

  Fly   349 -----EAAAAATSKDEIDPATGQRRHSVGLRSILLKGQMFYIKD--VDSLIFLCSPLIENLDELH 406
                 |....:.|..:::|:......::....||.|.:.:.|.|  .|     |..::.|:.:
Worm   720 LWVAPEVLRGSLSVSQMEPSADIYSFAIIASEILTKKEAWDILDRKED-----CEEIVYNVKK-- 777

  Fly   407 GIGLY---------LNDLNPHGLSRELVMAGWQH-----------CSKLEIMFEKE--------- 442
            | ||:         ::|:||..::  ||...|..           ||:::.:..|:
Worm   778 G-GLFPIRPEIITDIHDVNPALIA--LVKDCWAEVPEDRPTAENICSQMKGLVSKQKTNLMDHVF 839

  Fly   443 ----------EQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIF 497
                      |:..:|..|.|.|.   |::.|.||..|:|:.:|||::..:....:.|:.|:|.|
Worm   840 NMLEEYTSTLEEEIEERTKELTLE---KKKADILLSRMLPKQVAERLKAGQTVEPEGFDSVTVFF 901

  Fly   498 IEVMNIYDSGSNNIQDAMQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNP-LHA 561
            .:|:......|.  ....|.|..||.::|..|..|....|||||::|..|:.|||.|..|. .|.
Worm   902 SDVVKFTILASK--CSPFQTVNLLNDLYSNFDTIIEQHGVYKVESIGDGYLCVSGLPTRNGYAHI 964

  Fly   562 EHACDLALRVMKKVKAHALP-----GVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMES 621
            :...|::|:.|:..|:..:|     .|.:|:|:||||.||||||:.:||||||||||||||||||
Worm   965 KQIVDMSLKFMEYCKSFNIPHLPRENVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMES 1029

  Fly   622 SSDPWMIQLSN--YTALKVQKVG-YKVEARGFVKVKGKGEMETYWL 664
            :..|.:|.|:|  ::.|...... |:..:||.|.:||||.|||:|:
Worm  1030 NGKPSLIHLTNDAHSLLTTHYPNQYETSSRGEVIIKGKGVMETFWV 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	14/56 (25%)
		HNOBA	218..479	CDD:400168	70/349 (20%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	79/186 (42%)
gcy-1	NP_496039.1	PBP1_NPR_GC_like	35..449	CDD:107347	3/7 (43%)
		ANF_receptor	53..432	CDD:279440
		PKc_like	555..821	CDD:304357	54/290 (19%)
		HNOBA	<840..883	CDD:285003	13/45 (29%)
		CYCc	862..1051	CDD:214485	77/193 (40%)
		Guanylate_cyc	889..1077	CDD:278633	79/189 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810