DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Db and acy-2

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_504553.1	Gene:	acy-2 / 191607	WormBaseID:	WBGene00000069	Length:	1080	Species:	Caenorhabditis elegans

Alignment Length:	380	Identity:	86/380 - (22%)
Similarity:	163/380 - (42%)	Gaps:	96/380 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   371 VGLRSILLKGQMFYIKDVDSLIFLCS------------------------------PLIENLDEL 405
            :|...|:.|.::..:...:|||||.|                              .::.:|...
Worm   687 IGPHIIIKKSKLEGVMAFNSLIFLPSCVSHLVSVFILYRLPYSHRCFLFFADFVIFQVLLSLFPA 751

  Fly   406 HGIGLYLNDLNPH----GLSRELVMA-----GW------QHCSKLEIMFEKEEQRSDELEKSLEL 455
            :|..:|:..:..|    .:|..|::.     .|      :..|...:.|:.||:..:.::...::
Worm   752 YGAEVYVGYMGYHLSVVSISLSLLVVLLFFIDWITNYERKRESACHVSFQNEERDVETMQDINKI 816

  Fly   456 ADSWKRQGDELLYSMIPRPIAERM----RKSEEHVCQSFEEVSVIFIEVMNIYDSGSN-NIQDAM 515
                      |:.:::|..:|.:.    |...|...:..|.|.|:|..:.|..|..|. :....:
Worm   817 ----------LIENILPSSVAAKFLSPDRAVNELYARQHENVCVMFASIPNFKDFWSEWDTNRKL 871

  Fly   516 QAVTTLNKVFSALDEEIISP---FVYKVETVGMVYMAVSG----APDVNPLHAE----------- 562
            :.:..||::....|:.:..|   .|.|::|||..|||.:|    ..|.:.::.|
Worm   872 ECLRLLNEIVCEFDKLLSKPKFSSVEKIKTVGSTYMAAAGLNESEADYDDIYLEKQNSGKYNNNI 936

  Fly   563 -HACDLALR--------------VMKKVKAHALPGVAIRVGINSGPVVAGVVGMKVPRYCLFGDT 612
             |. ::|.|              ::..:...:.....:|:|::.||:||||:|.:.|:|.::|:|
Worm   937 RHG-NMAFRNANLMIEFALAMSQILDALNRDSFQNFELRIGMSVGPLVAGVIGAQKPQYDIWGNT 1000

  Fly   613 VNTASRMESSSDPWMIQLSNYTALKVQKVGYKVEARGFVKVKG-KGEMETYWLLE 666
            ||.||||::..:|..|..:......:|..||:|::||.::||| |..|||: |:|
Worm  1001 VNLASRMDTHGEPRKIHATTDMGRVLQTGGYRVQSRGKIRVKGVKEPMETF-LIE 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167
		HNOBA	218..479	CDD:400168	23/152 (15%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	59/211 (28%)
acy-2	NP_504553.1	CYCc	253..463	CDD:214485
		Guanylate_cyc	308..459	CDD:278633
		CYCc	817..1034	CDD:214485	54/217 (25%)
		Guanylate_cyc	840..1054	CDD:278633	60/215 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810