DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Db and gcy-20

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_507101.1	Gene:	gcy-20 / 184797	WormBaseID:	WBGene00001545	Length:	1108	Species:	Caenorhabditis elegans

Alignment Length:	695	Identity:	177/695 - (25%)
Similarity:	279/695 - (40%)	Gaps:	168/695 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GMLYESVQHYIQQEYGMETWRKVCQIVDCKHQSFKTHQIYPDKLMPDFAAALSASTGESFDFCMN 67
            |:||  ..|..::|  ||....:.|:...:.|..:: :...:..|..||:..|.||.      |.
Worm   495 GLLY--TMHMKRKE--MERQDLLWQVAFVELQQVQS-KSRAEASMHSFASGPSTSTK------MT 548

  Fly    68 FFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPKMKSPSMQLTNMDDDGAVIL 132
            ...|.....|..:.|.:.:.:..::  |.|...|          ...||...|:.|.|:|.
Worm   549 VESRTETTNFIFYHYHQEVVAAKKH--DLLVLFD----------ANQKSEFRQMRNFDNDN---- 597

  Fly   133 YRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLTEGPLTVIVKYRLDFD 197
                               ..:|.||.:....|.|....|         :.|.|:
Worm   598 -------------------LNKFIGLCLDGPQLLSLWRFC---------SRGSLS---------- 624

  Fly   198 NRDYMAKRVNVIAHPSQLKMPSVDLNVFLELFPFTIVLDHDMKITLAGEKIVETWILHNPGVNPK 262
              |.::|        |.::|.|        .|.|:::.|....:          :.:|:
Worm   625 --DVISK--------SSMQMDS--------FFMFSLIRDISNGL----------YFIHS------ 655

  Fly   263 TFIGSHILERFKCRRPKDTQIQWETILQMRTVLFEFELIRTGHNR-------AAYDAALNFDFEN 320
            :|:..|.....:|....|   :|    |::...|..:.:||..|.       |:.:...|.|.|.
Worm   656 SFLKCHGQLTSRCCLIDD---RW----QIKISGFGLKSVRTFENPKKEDLLWASPEYLRNEDQER 713

  Fly   321 FDEAS--SLNEAQAMALASAKEFSAENAKE--EAAAAATSKDEIDPA-----TGQRRHSVGLRSI 376
            ..|..  |.....|..|..:..|..||.||  :.......|...:|.     ||:   :|.:...
Worm   714 LPEGDIYSFGIICAEILTRSSAFDLENRKEKPDVIIYQVKKGGHNPTRPSLDTGE---TVVINPA 775

  Fly   377 LLKGQMFYIKDVDSLIFLC-------SPLIENL-DELHGIGLYLNDLNPHGLSRELVMAGWQHCS 433
            ||    ..::|       |       .|.||.: ..|:|    :.|.....|...:......:.|
Worm   776 LL----HLVRD-------CWTERPSERPSIEQVRSHLNG----MKDGRKTNLMDHVFNMLETYAS 825

  Fly   434 KLEIMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFI 498
            .||   |:...|:.||.:.       |::.|.|||.|:||.:|::::..:....::||:|::.|.
Worm   826 TLE---EEVSDRTKELTEE-------KKKSDVLLYRMLPRMVADKLKLGQTVEPETFEQVTIFFS 880

  Fly   499 EVMNIYDSGSNNIQDAMQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPL-HAE 562
            :|:........  ...:|.||.||.:::..|..|....||||||:|..|:.|||.|..|.. |..
Worm   881 DVVQFTTLAGK--CTPLQVVTLLNDLYTIFDGIIEQNDVYKVETIGDGYLCVSGLPHRNGNDHIR 943

  Fly   563 HACDLALRVMKKV---KAHALPG--VAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESS 622
            |...::|..:..:   :...||.  :.:|:|||.|.|||||||:.:||||||||.|||||||||:
Worm   944 HIARMSLGFLSSLEFFRVQHLPAERINLRIGINCGSVVAGVVGLTMPRYCLFGDAVNTASRMESN 1008

  Fly   623 SDPWMIQLSNYTALKVQKV--GYKVEARGFVKVKGKGEMETYWLL 665
            ..|..|.::......:.:|  |::.|:||.|.:||||.|||:|||
Worm  1009 GKPGQIHVTAEANRMLTQVVGGFRTESRGEVIIKGKGVMETFWLL 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	31/157 (20%)
		HNOBA	218..479	CDD:400168	60/284 (21%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	75/184 (41%)
gcy-20	NP_507101.1	PBP1_NPR_GC_like	22..439	CDD:107347
		ANF_receptor	44..418	CDD:279440
		PKc_like	536..801	CDD:304357	70/379 (18%)
		STYKc	562..801	CDD:214568	62/347 (18%)
		HNOBA	<818..861	CDD:285003	16/52 (31%)
		CYCc	840..1032	CDD:214485	72/200 (36%)
		Guanylate_cyc	867..1054	CDD:278633	77/189 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810