DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Db and gcy-32

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_506452.5	Gene:	gcy-32 / 179887	WormBaseID:	WBGene00001552	Length:	684	Species:	Caenorhabditis elegans

Alignment Length:	704	Identity:	185/704 - (26%)
Similarity:	313/704 - (44%)	Gaps:	117/704 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGMLYESVQHYIQQEYGMETWRKVCQIVDCKHQSFKT------HQIYPDK----LMPDFAAALS 55
            |:|.::||::..:.:.||.:||.:|.:     ...|::      :..|.|.    |:...:..|.
Worm     1 MFGFIHESIRQLVIRNYGEDTWTQVLE-----RSGFESGKENIMNHYYSDTDTYVLVDSVSLVLK 60

  Fly    56 ASTGESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPK--MKSPS 118
            .:..:.::    .:|...:.:....|:|:::||.......||.::|::|..:.....|  ::.||
Worm    61 VTKDQVWE----MYGGFLITYSMEIGWDELVRSMSPNLKGFLDNLDSLHYFIDHVVYKANLRGPS 121

  Fly   119 MQLTNMDDDGAVILYRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPIKLTE 183
            .:.....|...::.|.:||.|:...:.|.:.||||..:.||:|..|.       |.|...:.:..
Worm   122 FRCEETPDGTLLLHYFTGRPGLYHIVKGVVKEVAKRVFDLDITLVVQ-------GRTQRSVHMNN 179

  Fly   184 GPL----TVIVKYRLDFDNRDYMAKRVNVIAHPSQLKMPS-------VDLNVFLELFPFTIVLDH 237
            |..    .|.:...|....||.....|:::. .:....|:       :.|:.|.:..|:..|:|.
Worm   180 GERVEEHVVFLINNLSEPRRDSEGSEVSLLT-STNANFPTIVDDTLGISLDDFSKALPYHFVIDE 243

  Fly   238 DMKITLAGEKIVETWILHNPGVNPKTFIGSHILERFKCRRPKDTQIQWETILQMRTVLFEFEL-- 300
            ..|:...|.:      |||...|.....|:.||..|:..||: ..:.:|.|......:|..::
Worm   244 SCKLVQCGSE------LHNHIPNELLQPGTPILRIFEINRPQ-IPLDFENICNFINAVFVLQVKT 301

  Fly   301 --IRTGHNRAAYDAALNFDFENFDEASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPA 363
              ::..|..|.....|..:.|..|| .:.||..
Worm   302 SPLKKKHMDAMSQEELKQEMETLDE-DATNELT-------------------------------- 333

  Fly   364 TGQRRHSVGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAG 428
              |..|      :.|||||..:.....:|:||||.:.:::||...|:.|..:..|..:|:|::..
Worm   334 --QGHH------LKLKGQMMLLASKKHIIYLCSPYVTSINELMQYGMRLTAMPLHDATRDLILLN 390

  Fly   429 WQHCSKLEI--MFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFE 491
            .|..|.:|:  ..|...::.:.:.:.|||.   :::.|.:|..|:||.||::: .|.||:.....
Worm   391 QQRLSDVEVNLQLEANNEQLETMTRELELE---RQKTDSILKDMLPRRIAQQL-LSGEHIEACEH 451

  Fly   492 EVSVIFIEVMNIYDSGSNNIQDAM------QAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAV 550
            |.:|:|.::        ...|.|:      ..|..||::|..||..::...|||||||...||||
Worm   452 EATVMFCDL--------PAFQQAIPQCSPKDIVNMLNEIFRKLDRIVVIRGVYKVETVSDSYMAV 508

  Fly   551 SGAPDVNPLHAEHACDLALRVMKKVKAHALP----GVAIRVGINSGPVVAGVVGMKVPRYCLFGD 611
            ||.||..|.|||:.|.:||.:|.:.::...|    ...:|:||:||.:.|||||...|:|||||:
Worm   509 SGIPDYTPEHAENMCHVALGMMWEARSVIDPVSKTPFLLRIGIHSGTITAGVVGTVHPKYCLFGE 573

  Fly   612 TVNTASRMESSSDPWMIQLSNYTALKVQKVG-YKVEARGFVKVKGKGEMETYWL 664
            ||..||:|||......||.|.:...|..:.| ::...||.:.||.:|..|||:|
Worm   574 TVTLASQMESLGMAGKIQCSKWAYQKAMETGRFEFSPRGRIDVKQRGLTETYFL 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	37/170 (22%)
		HNOBA	218..479	CDD:400168	62/273 (23%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	72/188 (38%)
gcy-32	NP_506452.5	HNOB	3..167	CDD:285002	38/172 (22%)
		HNOBA	226..440	CDD:285003	61/264 (23%)
		CYCc	419..608	CDD:214485	74/200 (37%)
		Guanylate_cyc	452..627	CDD:278633	71/182 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.780