DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Db and acy-4

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_504486.4	Gene:	acy-4 / 178949	WormBaseID:	WBGene00000071	Length:	1013	Species:	Caenorhabditis elegans

Alignment Length:	256	Identity:	76/256 - (29%)
Similarity:	112/256 - (43%)	Gaps:	58/256 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   459 WKRQG-DELLYSMIPRPIAERMRKSEE-----------HVCQSFEEVSVIFIEVMNIYDSGSNNI 511
            ||.|. ||.|         :..||.|:           ||.:.|.|.:.   .|..:|....:|.
Worm   763 WKLQALDEQL---------QMKRKHEQNRSVLENILPSHVAKHFVEDAT---SVSKLYHESRDNA 815

  Fly   512 QDAMQAVTTLNKVFSALD------------EEIISPF---------------VYKVETVGMVYMA 549
            ......:|..:|.:...|            .||||.|               :.|::|:...||.
Worm   816 CIMFATLTEFDKFYIECDGNNEGVECLRLLNEIISDFDQILDQILDREEFKKIEKIKTISTTYMV 880

  Fly   550 VSGAPD---VNPLHAEHACDLALRVMKKVKA---HALPGVAIRVGINSGPVVAGVVGMKVPRYCL 608
            .||...   .:..|.|.....|..::.|:::   |:.....:|:|||.|||||||:|...|.|.:
Worm   881 ASGLAGRECGDNSHVEAIALFARELLVKLESTNIHSFNNFNLRIGINVGPVVAGVIGSDKPHYDI 945

  Fly   609 FGDTVNTASRMESSSDPWMIQLSNYTALKVQKVGYKVEARGFVKVKGKGEMETYWLLEGPE 669
            :|::||.||||:|......||::......::.:||..|.||.:.|||||.|||::||. ||
Worm   946 WGNSVNVASRMDSGGVAGRIQVTEEVKSILEPLGYNFECRGQINVKGKGMMETFFLLP-PE 1005

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167
		HNOBA	218..479	CDD:400168	6/20 (30%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	61/209 (29%)
acy-4	NP_504486.4	AC_N	<50..291	CDD:292831
		CYCc	260..451	CDD:214485
		Guanylate_cyc	293..448	CDD:278633
		CYCc	778..984	CDD:214485	53/208 (25%)
		Guanylate_cyc	807..1003	CDD:278633	59/195 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810