DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Db and gcy-18

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_502449.2	Gene:	gcy-18 / 178237	WormBaseID:	WBGene00001543	Length:	1113	Species:	Caenorhabditis elegans

Alignment Length:	666	Identity:	162/666 - (24%)
Similarity:	265/666 - (39%)	Gaps:	160/666 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 VRFFSNFGY---DKMIRSTGRYFCDFLQSIDNIHVQMRFTYPKMKSPSMQLTNMDDDGAVILYRS 135
            |.||..|.|   .::.:...|.|.|.||.||...|:...:   :.|.:.:|:|:
Worm   514 VVFFFLFRYCENKQLEKMPWRIFHDDLQFIDEEQVKSMMS---VGSVTTKLSNI----------- 564

  Fly   136 GRTGMSKY-LIGQMTEVAKEFY-----------GLDMTAYVLESQNDICGGTAGPIKLTEGPLTV 188
             :||..:: :||..|......|           .:.:...:.::.:|......|.....:..:.|
Worm   565 -QTGQKQHAIIGVNTHTTYHRYKQRRPIKFIKEDMQLLTQMKQAVHDNLNPFLGAAFNEKEEMLV 628

  Fly   189 IVKY--RLDFDNRDYMAKRVNVIA----HPSQLKMPSVDLNVFLE------------LFPFTIVL 235
            :.|:  |....:..|.|   ||:.    |.:.::    |:.:.||            |.|:..::
Worm   629 LWKFCSRGTIQDIIYNA---NVVLDEKFHGAFVR----DITLGLEYLHASPIGYHGSLTPWCCLI 686

  Fly   236 DHDMKITLAGEKIVETWILHNPGVNPKTFIGSHILERFKCRRPKDTQIQWETILQMRTVLFEFEL 300
            |.:..:.|:...|          .||        |||            ||
Worm   687 DRNWMVKLSDYGI----------ANP--------LER------------WE-------------- 707

  Fly   301 IRTGHNRAAYDAALNFDFENFDEASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATG 365
                 .:.|.:.|...|.::..:||.......||....|  :.|..|......:..|..:.....
Worm   708 -----KQGAIEIAAAKDSDDKSQASQATSIIYMAPELLK--NRETNKRRGMDQSWVKQSMLRRQA 765

  Fly   366 QRRHSVG--LRSILLKGQMF-----------YIKDVDSLIFLCSPLIENLDELH-GIGLYLNDL- 415
            ...:|.|  :..||.:...|           |:.|....:   ||.|:|...|| .:...|.|.
Worm   766 GDIYSFGMVMYEILFRSLPFRDNTNISELVDYLADGSKTV---SPEIQNQMGLHPDLNALLRDCW 827

  Fly   416 --NPH--------GLSRELVMAGWQHCSKLEIMFEKEEQRSDELEK-------SLELADSWKRQG 463
              ||.        .|:.|:|:.  ...|.::.|.:..||.::.|||       .||.|:.   :.
Worm   828 SENPEIRPSIRRVRLNTEMVLK--TKGSLVDQMMKMMEQYANNLEKLVAERTGMLEEANI---RA 887

  Fly   464 DELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYD--SGSNNIQDAMQAVTTLNKVFS 526
            |:||..::|..:|..::.......:.:...:::|.:::....  |||.    .::.|..||.:::
Worm   888 DQLLTQLLPAYVANELKMGRSVAPKLYSSATILFSDIVGFTTICSGST----PLEVVNMLNGLYT 948

  Fly   527 ALDEEIISPFVYKVETVGMVYMAVSGAPDVNPL-HAEHACDLALRVMKKVKAHALP-----GVAI 585
            ..||.|.....|||||:|..||.|||.|:.|.. |:.:..:.||.:.:.:..:.:|     .|..
Worm   949 GFDECITRNKSYKVETIGDAYMVVSGIPEENEYNHSRNIANTALDMRQYLTGYQIPHRPTHRVRC 1013

  Fly   586 RVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSN--YTALKVQKVGYKVEAR 648
            |.|.::|.|.|||||:..|||||||||||.:|||||:..|.|||:|.  :..::.....:....|
Worm  1014 RWGFHTGSVAAGVVGLTCPRYCLFGDTVNVSSRMESTGTPGMIQMSEEAHMHIRAHHPVFTTTER 1078

  Fly   649 GFVKVKGKGEMETYWL 664
            |.|:|||||...|:||
Worm  1079 GEVQVKGKGTCRTFWL 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	22/101 (22%)
		HNOBA	218..479	CDD:400168	61/304 (20%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	69/187 (37%)
gcy-18	NP_502449.2	Periplasmic_Binding_Protein_Type_1	87..448	CDD:299141
		ANF_receptor	87..395	CDD:279440
		PKc_like	549..846	CDD:304357	63/372 (17%)
		HNOBA	<857..903	CDD:285003	14/48 (29%)
		CYCc	882..1073	CDD:214485	64/197 (32%)
		Guanylate_cyc	909..1095	CDD:278633	69/190 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810