DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Db and acy-1

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_497970.1	Gene:	acy-1 / 175622	WormBaseID:	WBGene00000068	Length:	1253	Species:	Caenorhabditis elegans

Alignment Length:	351	Identity:	99/351 - (28%)
Similarity:	153/351 - (43%)	Gaps:	60/351 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 EFSAENAKEEAAAAATSKDEIDPATGQRRHSVGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDE 404
            ||:.::..||......:...|.|......:::.|.|...:   ...:|..|.:|:...|   ||.
Worm   919 EFNLKHLVEEQDTCNVTAIMIPPIRKGLNYTIALNSTSAR---TLSQDFGSPLFIWELL---LDV 977

  Fly   405 LHGIGL--YLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLELADSWKRQGDELL 467
            :..|.|  :||               :|..:...:.|..:.|...:.|:...:.|    |.|.||
Worm   978 ILSIVLVAFLN---------------YQFETAFRMSFFGDVQARRDTERMQIVRD----QADWLL 1023

  Fly   468 YSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYDSGSNNIQDAMQAVTTLNKVFSALDEEI 532
            .::||....|.: |::....::.|.|.|:|..:.|..|....|.:...:.:..||:|....||.:
Worm  1024 NNVIPAHAVESL-KTDTKYSENHETVGVLFASITNWNDMYEENFEGGREFLRVLNEVIGDFDELL 1087

  Fly   533 ISP---FVYKVETVGMVYMAVSGAPDVNP------LH-AEH---ACDLALRVMKKVKAHALP--- 581
            ..|   .:.|::|:|..|||.||   :||      || .||   ..|.||.|.     |.|.
Worm  1088 DRPDFTHIEKIKTIGPAYMAASG---LNPERKKNMLHPKEHLYQMVDFALAVQ-----HVLSVFN 1144

  Fly   582 ------GVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQK 640
                  ....::|:|.|||.|||:|.....|.::|||||.||||.|:.....||:|.:|. :...
Worm  1145 EDLLNFDFVCKLGLNIGPVTAGVIGTTKLYYDIWGDTVNIASRMYSTGVLNRIQVSQHTR-EYLL 1208

  Fly   641 VGYKVEARGFVKVKG-KGEMETYWLL 665
            ..|:.|.|..::||| .|.|:||.|:
Worm  1209 DRYEFEFRDHIEVKGIDGGMDTYLLV 1234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167
		HNOBA	218..479	CDD:400168	30/140 (21%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	67/199 (34%)
acy-1	NP_497970.1	MreD	127..>223	CDD:294686
		CYCc	297..469	CDD:214485
		Guanylate_cyc	317..503	CDD:278633
		SDF	<773..982	CDD:294387	14/68 (21%)
		CYCc	1016..1215	CDD:214485	67/212 (32%)
		Guanylate_cyc	1041..1235	CDD:278633	68/203 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810