DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Db and gcy-29

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001364597.1	Gene:	gcy-29 / 175116	WormBaseID:	WBGene00007314	Length:	1069	Species:	Caenorhabditis elegans

Alignment Length:	245	Identity:	74/245 - (30%)
Similarity:	127/245 - (51%)	Gaps:	20/245 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   435 LEIMFEKEEQRSDELEKSL----ELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSV 495
            ::.|....|:.::.|||.:    :||:....:.:.||:.::|:.:|..::.......:.::..:|
Worm   813 VDSMMRMMEEYANNLEKLVGERTKLAEEANLRAERLLFQLLPKHVAIELKAGRTVAPKMYDSATV 877

  Fly   496 IFIEVMNIYDSGSNNIQDA---MQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVN 557
            :|.:::     |...:..|   ::.|..|||::|..|..|.....|||||:|..||.|||.|..|
Worm   878 MFSDIV-----GFTKLCSASTPIEVVNLLNKLYSEFDTVISKHDCYKVETIGDAYMVVSGIPIEN 937

  Fly   558 -PLHAEHACDLALRVMKKVKAHALP-----GVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTA 616
             ..|..:...:.|.:|..:|...:|     .:.||:|..||.|.|.|||:..|||||||:|||.|
Worm   938 GQRHVANISAVTLGIMDLLKVFEVPHRRDYRLTIRLGFASGQVSAAVVGLSSPRYCLFGETVNIA 1002

  Fly   617 SRMESSSDPWMIQLSNYTALKVQK--VGYKVEARGFVKVKGKGEMETYWL 664
            :.||||.:...:|::..:.:.::.  ..:.:|.||..|...:.:..||||
Worm  1003 AVMESSGEGGRVQITETSKILLENEYPEFIIEIRGINKDVKQDDFVTYWL 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167
		HNOBA	218..479	CDD:400168	11/47 (23%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	63/188 (34%)
gcy-29	NP_001364597.1	PBP1_NPR_GC-like	27..403	CDD:380575
		PKc_like	534..804	CDD:419665
		CYCc	840..1033	CDD:214485	59/197 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810