DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Db and gcy-28

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001021600.1	Gene:	gcy-28 / 172051	WormBaseID:	WBGene00020131	Length:	1276	Species:	Caenorhabditis elegans

Alignment Length:	748	Identity:	184/748 - (24%)
Similarity:	294/748 - (39%)	Gaps:	212/748 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 TWRKVCQIVDCKHQSFKTHQIYPDKLMPDFAAALSASTGESFDFCMNFFGRCFVRFFSNFGYDKM 85
            |.||:..::|.|...|...:..|    |..:......|..|.....|  |.|
Worm   621 TTRKISAMIDRKLSIFTRKKSTP----PSESQKNGGLTPNSLQKAEN--GDC------------- 666

  Fly    86 IRSTGRYFCDFLQSIDNIHVQMRFTYPKMKSPSMQLT-----NMDD--DGA-------------- 129
                        ..|:.:..::.....::.|||.:.|     |.:|  :||
Worm   667 ------------SPINEVQFRLPLNDRRVSSPSSEATRKKNSNEEDPENGAKKSLSLKNRKLSFG 719

  Fly   130 VILYRSGRTGMSKYLIGQMTEVAKEFYGLDMTAYVLESQNDICGGTAGPI-KLTEGPLTVIVKY- 192
            ::.::||..|..:.:....|::              .::..|..|....| ||...|    .||
Worm   720 MVSFKSGSGGSVETIAQNNTQI--------------YTKTAIFKGVVVAIKKLNIDP----KKYP 766

  Fly   193 RLDFDNRDYM-AKRVNVIAHPSQLKM-----------------PSVDLNVFLELFPFTIVLDHDM 239
            |||......| .|::..:.|....:.                 |...|...||  ...|.||..|
Worm   767 RLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILE--NEKIELDKLM 829

  Fly   240 KITLAGEKIVETWILHNPGVNPKTFIGSH-ILERFKCRRPKDTQIQWETILQMRTVL--FEFELI 301
            |.:|..:.:...:.|||      :.|.|| .|:...|            ::..|.||  .:|.|.
Worm   830 KYSLLHDLVKGLFFLHN------SEIRSHGRLKSSNC------------VVDSRFVLKVTDFGLH 876

  Fly   302 RTGHNRAAYDAALNFDFENFDEASSLNEAQAMALASAKEFSAENAKEEA-------AAAATSKDE 359
            |                                |...:|.:.|...|.|       .|....:|.
Worm   877 R--------------------------------LHCLEEINLEEIGEHAYYKKMLWTAPELLRDS 909

  Fly   360 IDPATGQRRHSVGLRSILLKGQMFYIKDVDSL-----------IFLCSPLIENLDELH------G 407
            ..|..|.::..:...:|:|. :|.:.|.|.:|           ..:..|:.|:.:.|.      |
Worm   910 NAPPMGTQKGDIYSFAIILH-EMMFRKGVFALENEDLSPNEIVQRVRKPVSEDQEPLRPWVSETG 973

  Fly   408 IGLYLNDLNPHGLSRELVMAGW------------------------QHCSKLEIMFEKEEQRSDE 448
            .|...:.||...||  |::|.|                        :..:.::.:.::.||.::.
Worm   974 EGEGDDALNDTLLS--LMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANN 1036

  Fly   449 LEKSLE------LADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYDSG 507
            ||..:|      ||:  |::.:|||:.::|..||:.:........:|::.|::.|.:::......
Worm  1037 LEGLVEERTQEYLAE--KKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLS 1099

  Fly   508 SNNIQDAMQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLALRVM 572
            |.:  ..||.||.||.::.|.|..:.:..||||||:|..||.|||.|:....||.....::|.::
Worm  1100 SQS--TPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDDHANQIAQMSLSLL 1162

  Fly   573 KKVKAHAL-----PGVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSN 632
            .|||...:     ..:.:|:|::||.|||||||.|:||||||||||||:|||||:..|..|.:|.
Worm  1163 HKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQ 1227

  Fly   633 YT-ALKVQKVGYKVEARGFVKVKGKGEMETYWL 664
            .| .:.:|:.|:|:|.||.|::||||...||||
Worm  1228 QTYDILMQEAGFKLELRGSVEMKGKGMQTTYWL 1260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	26/160 (16%)
		HNOBA	218..479	CDD:400168	65/317 (21%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	79/183 (43%)
gcy-28	NP_001021600.1	PBP1_NPR_like	42..486	CDD:107368
		ANF_receptor	64..465	CDD:279440
		PK_GC-A_B	722..1016	CDD:270944	69/366 (19%)
		STYKc	741..1008	CDD:214568	65/339 (19%)
		HNOBA	<1026..1071	CDD:285003	14/46 (30%)
		CYCc	1050..1233	CDD:214485	72/186 (39%)
		Guanylate_cyc	1077..1262	CDD:278633	79/186 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910