DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Db and Gucy2c

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001120790.1	Gene:	Gucy2c / 14917	MGIID:	106903	Length:	1072	Species:	Mus musculus

Alignment Length:	770	Identity:	178/770 - (23%)
Similarity:	294/770 - (38%)	Gaps:	207/770 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 YPDKL----MPDFAAALSASTGESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDN 102
            |.|.:    :|...:..:.|..|.|....:.|...::.....||:  |:::       ||::.:|
Mouse   290 YMDNVLVLTLPSEQSTSNTSVAERFSSGRSDFSLAYLEGTLLFGH--MLQT-------FLENGEN 345

  Fly   103 IHVQMRFTYPKMKSPSMQLT--------NMDDDGAV-----ILYRSGRTGMSKYLIGQMTEVAKE 154
            :      |.||.......||        .:||.|.:     :||.|..|...|.|:...|...|.
Mouse   346 V------TGPKFARAFRNLTFQGFAGPVTLDDSGDIDNIMSLLYVSLDTRKYKVLMKYDTHKNKT 404

  Fly   155 FYGLDMTAYVLESQ---NDICGGTAGP--------------IKLTEGPLTVIVKYRLDFDNRDYM 202
            ....:...::.::.   ||:.|  .||              :.|....|.|:.|||     ||:.
Mouse   405 IPVAENPNFIWKNHKLPNDVPG--LGPQILMIAVFTLTGILVVLLLIALLVLRKYR-----RDHA 462

  Fly   203 AKRVNVIAHPSQLKMPSVDLNVFLELFPFTIVLDHD----------------MKITLAG------ 245
            .::......||:...| ::.|   |....::.:|.|                .|:.|..
Mouse   463 LRQKKWSHIPSENIFP-LETN---ETNHISLKIDDDRRRDTIQRVRQCKYDKKKVILKDLKHSDG 523

  Fly   246 -----EKIVETWILHNPGVNPKTFIGS-----------HILERFKCRR--------PKDTQIQWE 286
                 :||....:|.:...|...|.|:           ...||...|.        |..|.:.||
Mouse   524 NFSEKQKIDLNKLLQSDYYNLTKFYGTVKLDTRIFGVVEYCERGSLREVLNDTISYPDGTFMDWE 588

  Fly   287 TILQMRTVLFEFELIRTGHNRAAYDAALNFDF------ENFDEASSLN-EAQAMALASAKEFSAE 344
                     |:..::.        |.|....:      |......|.| ...:..:....:|...
Mouse   589 ---------FKISVLN--------DIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGCN 636

  Fly   345 NAKEEAAAAATSKDEIDPATGQRR-----HSVGLRSILLKGQMFY---IKDVDSLIFLCSP---- 397
            :.........|:.:.:..||..::     .::..:.|:|:.:.||   .:|.:..||....
Mouse   637 SILPPKKDLWTAPEHLRQATISQKGDVYSFAIIAQEIILRKETFYTLSCRDHNEKIFRVENSYGK 701

  Fly   398 ------LIENLDELHGIGLYLNDLNPHGLSRELVMAGWQH--------------CSKLEIMF--E 440
                  .:|..||.. :.:||           ||.:.|:.              .:|:..:|  :
Mouse   702 PFRPDLFLETADEKE-LEVYL-----------LVKSCWEEDPEKRPDFKKIESTLAKIFGLFHDQ 754

  Fly   441 KEEQRSDEL---------------EKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSF 490
            |.|...|.|               |:..:|..:.:.:.|.|.:.::||.:.:.:::......:.:
Mouse   755 KNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADHLNFMLLPRLVVKSLKEKGIVEPELY 819

  Fly   491 EEVSVIFIEVMNIYDSGSNNI---QDAMQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSG 552
            |||::.|.:::     |...|   ...|:.|..||.::.:.|:.:....||||||:|..|:..||
Mouse   820 EEVTIYFSDIV-----GFTTICKYSTPMEVVDMLNDIYKSFDQIVDHHDVYKVETIGDAYVVASG 879

  Fly   553 APDVN-PLHAEHACDLALRVMKKV---KAHALPG--VAIRVGINSGPVVAGVVGMKVPRYCLFGD 611
            .|..| ..||.....:||.::..:   :...|||  |.||:|::|||..|||||:|:||||||||
Mouse   880 LPMRNGNRHAVDISKMALDILSFIGTFELEHLPGLPVWIRIGVHSGPCAAGVVGIKMPRYCLFGD 944

  Fly   612 TVNTASRMESSSDPWMIQLSN--YTALKVQKVGYKVEARGFVKVKGKGEMETYWL 664
            ||||||||||:..|..|.:|:  .|.||.....:..|.||...:||:|...||||
Mouse   945 TVNTASRMESTGLPLRIHMSSSTITILKRTDCQFLYEVRGETYLKGRGTETTYWL 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	29/135 (21%)
		HNOBA	218..479	CDD:400168	57/362 (16%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	77/188 (41%)
Gucy2c	NP_001120790.1	Periplasmic_Binding_Protein_Type_1	35..415	CDD:299141	29/139 (21%)
		PKc_like	480..749	CDD:304357	45/300 (15%)
		STYKc	502..744	CDD:214568	40/270 (15%)
		CYCc	787..978	CDD:214485	71/195 (36%)
		Guanylate_cyc	814..1001	CDD:278633	77/191 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810