DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Db and Npr2

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_446290.1	Gene:	Npr2 / 116564	RGDID:	620851	Length:	1047	Species:	Rattus norvegicus

Alignment Length:	677	Identity:	172/677 - (25%)
Similarity:	285/677 - (42%)	Gaps:	185/677 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 PKMKSPSMQLTNMDDDG---------AVILYRSGRT----GMSKYLIGQMTEVAKEFYGLDMTAY 163
            |.:.:|.... ::||..         |::...:|.|    |:|.:||.:...:.||...:.....
  Rat   432 PPLDNPPCAF-DLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIR 495

  Fly   164 VLESQ---ND-------------ICGGTAGPIKLTEGPLTVIVKYRLDFDNRDYMAKRVNVIAHP 212
            ..|.|   :|             :.|.:.|.:....|      ||:: |.|..:....|..|.|.
  Rat   496 WEELQFGNSDRYHKGAGSRLTLSLRGSSYGSLMTAHG------KYQI-FANTGHFKGNVVAIKHV 553

  Fly   213 S------------QLK-MPSVDLN----------------VFLELFP----------FTIVLDHD 238
            :            :|| |..|..|                :..|..|          .:|.||..
  Rat   554 NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWM 618

  Fly   239 MKITLAGEKIVETWILHNPGVNPKTFIGSH-ILERFKCRRPKDTQIQWETILQMRTVLFEFELIR 302
            .:.:|..:.:.....|||      :.|.|| .|:...|            ::..|     |.|..
  Rat   619 FRYSLINDLVKGMAFLHN------SIISSHGSLKSSNC------------VVDSR-----FVLKI 660

  Fly   303 TGHNRAAYDAALNFDFENFDEASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATGQR 367
            |.:..|:        |.:..|....:...|..|.:|.|..:.|..              |.||.:
  Rat   661 TDYGLAS--------FRSTAEPDDSHALYAKKLWTAPELLSGNPL--------------PTTGMQ 703

  Fly   368 R-----HSVGLRSILLKGQMFYIKDVDSLIFLCSP--LIENLDELHGIGLYLN-DLNPHGLSREL 424
            :     .::.|:.|.|:...||::.:|     .||  :::.:  .:|...|.. .::...|:.||
  Rat   704 KADVYSFAIILQEIALRSGPFYLEGLD-----LSPKEIVQKV--RNGQRPYFRPSIDRTQLNEEL 761

  Fly   425 VMAGWQHC---------------------------SKLEIMFEKEEQRSDELEKSLE------LA 456
            |:. .:.|                           |.|:.:..:.||.::.|||.:|      |.
  Rat   762 VLL-MERCWAQDPTERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLE 825

  Fly   457 DSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYDSGSNNIQDAMQAVTTL 521
            :  ||:.:.|||.::|..:||::::.|....::|:.|::.|.:::......:.:  ..||.||.|
  Rat   826 E--KRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAES--TPMQVVTLL 886

  Fly   522 NKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVN-PLHAEHACDLALRVMKKVKAHAL----- 580
            |.:::..|..|.:..||||||:|..||.|||.|..| ..||.....:||.::..|.:..:
  Rat   887 NDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPH 951

  Fly   581 PGVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQKVG-YK 644
            ..:.:|:|:::|||.|||||:|:||||||||||||||||||:.....|.:|:.|...:.::| ::
  Rat   952 DQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQ 1016

  Fly   645 VEARGFVKVKGKGEMETYWLL---EGP 668
            :|.||.|::||||:|.|||||   :||
  Rat  1017 LELRGDVEMKGKGKMRTYWLLGERKGP 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167	13/61 (21%)
		HNOBA	218..479	CDD:400168	63/328 (19%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	75/183 (41%)
Npr2	NP_446290.1	PBP1_NPR_B	26..421	CDD:380607
		PK_GC-A_B	518..792	CDD:270944	59/333 (18%)
		HNOBA	<798..846	CDD:400168	16/49 (33%)
		CYCc	825..1009	CDD:214485	71/187 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810