DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Db and Adcy9

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_011244107.1	Gene:	Adcy9 / 11515	MGIID:	108450	Length:	1372	Species:	Mus musculus

Alignment Length:	306	Identity:	84/306 - (27%)
Similarity:	137/306 - (44%)	Gaps:	37/306 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   392 IFLC---SPLIENLDELHGIGLYLNDLN---------PHGL-SRELVMA-------GWQHCSKLE 436
            |.||   |.::..||.........|..|         |..| .:||::.       .|....:.|
Mouse   956 ISLCQDSSIVMSPLDSAQNFSAQRNPCNSSVLQDGRRPASLIGKELILTFFLLLLLVWFLNREFE 1020

  Fly   437 IMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVM 501
            :.:........|.:.......|.:.|.|.||.::||..:||:::.|:.: .::.:...|||..::
Mouse  1021 VSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTY-SKNHDSGGVIFASIV 1084

  Fly   502 NIYDSGSNNIQDAMQAVTTLNKVFSALDEEIISP---FVYKVETVGMVYMAVSGAPDVNPLHAEH 563
            |..:....|.:...:....||::....||.:..|   .:.|::|:|..|||.||..........|
Mouse  1085 NFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYNSIEKIKTIGATYMAASGLNTAQCQEGGH 1149

  Fly   564 ACDLALRVMKKVKAHALPGV------------AIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTA 616
            ..: .||::.:.....:..|            .:|||.|.||:.|||:|.....|.::|||||.|
Mouse  1150 PQE-HLRILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIA 1213

  Fly   617 SRMESSSDPWMIQLSNYTALKVQKVGYKVEARGFVKVKGKGEMETY 662
            |||:::.....||:|..:...:.|:||..:.||.|.|||||:|:||
Mouse  1214 SRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTY 1259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167
		HNOBA	218..479	CDD:400168	24/106 (23%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	59/190 (31%)
Adcy9	XP_011244107.1	MFS	<134..260	CDD:391944
		Guanylate_cyc	385..573	CDD:306677
		Guanylate_cyc	1069..1260	CDD:306677	59/193 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810