DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Db and ADCY6

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001377760.1	Gene:	ADCY6 / 112	HGNCID:	237	Length:	1168	Species:	Homo sapiens

Alignment Length:	374	Identity:	115/374 - (30%)
Similarity:	186/374 - (49%)	Gaps:	92/374 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 FENFDEASSLNEAQAMALASAKEFSAENAKEEAAAAATSKDEID-PATGQRRHSVGLRSILLKGQ 381
            |:|:|....::     .|||:.|               :.|.:| ||.|:         :.||
Human   862 FDNYDLLLGVH-----GLASSNE---------------TFDGLDCPAAGR---------VALK-- 895

  Fly   382 MFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRS 446
              |:..|..|:|             .:.|||:.......:|...:  |    ||:...||||.
Human   896 --YMTPVILLVF-------------ALALYLHAQQVESTARLDFL--W----KLQATGEKEEM-- 937

  Fly   447 DELEKSLELADSWKRQGDELLYSMIPRPIA----ERMRKSEEHVCQSFEEVSVIFIEVMNI---- 503
            :||:       ::.|:   ||::::|:.:|    .|.|:::|...||.|.|:|:|..:.|.
Human   938 EELQ-------AYNRR---LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFY 992

  Fly   504 YDSGSNNIQDAMQAVTTLNKVFSALDEEIISPFVY----KVETVGMVYMAVSGA-----PDVNPL 559
            .:..:||  :.::.:..||::.:..| ||||...:    |::|:|..|||.||.     ..|...
Human   993 VELEANN--EGVECLRLLNEIIADFD-EIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRS 1054

  Fly   560 HAEHACDLALRVMKKVK---AHALPGVAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMES 621
            |.....|.|:|:|:::|   .|:.....:::|:|.|||||||:|.:.|:|.::|:|||.:|||:|
Human  1055 HITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDS 1119

  Fly   622 SSDPWMIQLSN--YTALKVQKVGYKVEARGFVKVKGKGEMETYWLLEGP 668
            :..|..||::.  |..|..:  ||::|.||.|||||||||.||:|..||
Human  1120 TGVPDRIQVTTDLYQVLAAK--GYQLECRGVVKVKGKGEMTTYFLNGGP 1166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167
		HNOBA	218..479	CDD:400168	36/165 (22%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	73/194 (38%)
ADCY6	NP_001377760.1	AC_N	<16..368	CDD:318454
		Guanylate_cyc	370..554	CDD:306677
		DUF1053	582..668	CDD:399378
		Guanylate_cyc	970..1164	CDD:306677	74/198 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810