DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Db and ADCY5

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001365188.1	Gene:	ADCY5 / 111	HGNCID:	236	Length:	1286	Species:	Homo sapiens

Alignment Length:	270	Identity:	94/270 - (34%)
Similarity:	154/270 - (57%)	Gaps:	35/270 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   425 VMAGWQHCSKLE----IMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIA----ERMRK 481
            |:|.:.|..::|    :.|..:.|.::|.|:..|| .::.|:   ||::::|:.:|    .|.|:
Human  1023 VLALYLHAQQVESTARLDFLWKLQATEEKEEMEEL-QAYNRR---LLHNILPKDVAAHFLARERR 1083

  Fly   482 SEEHVCQSFEEVSVIFIEVMNI----YDSGSNNIQDAMQAVTTLNKVFSALDEEIISPFVY---- 538
            ::|...||.|.|:|:|..:.|.    .:..:||  :.::.:..||::.:..| ||||...:
Human  1084 NDELYYQSCECVAVMFASIANFSEFYVELEANN--EGVECLRLLNEIIADFD-EIISEDRFRQLE 1145

  Fly   539 KVETVGMVYMAVSGAPD-----VNPLHAEHACDLALRV---MKKVKAHALPGVAIRVGINSGPVV 595
            |::|:|..|||.||..|     |...|.:...|.|:::   ||.:..|:.....:::|:|.||||
Human  1146 KIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVV 1210

  Fly   596 AGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSN--YTALKVQKVGYKVEARGFVKVKGKGE 658
            |||:|.:.|:|.::|:|||.||||:|:..|..||::.  |..|....  |::|.||.||||||||
Human  1211 AGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANT--YQLECRGVVKVKGKGE 1273

  Fly   659 METYWLLEGP 668
            |.||:|..||
Human  1274 MMTYFLNGGP 1283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167
		HNOBA	218..479	CDD:400168	15/61 (25%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	73/194 (38%)
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454
		Guanylate_cyc	460..633	CDD:306677
		DUF1053	668..760	CDD:399378
		Guanylate_cyc	1087..1281	CDD:306677	74/198 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810