DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Db and ADCY2

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_065433.2	Gene:	ADCY2 / 108	HGNCID:	233	Length:	1091	Species:	Homo sapiens

Alignment Length:	325	Identity:	91/325 - (28%)
Similarity:	164/325 - (50%)	Gaps:	50/325 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   371 VGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQ---HC 432
            ||..:|||......:.|...::|....:.::|..:..:.|.:..:.       |::.|.|   :|
Human   771 VGYNTILLHTHAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFIT-------LLVLGRQNEYYC 828

  Fly   433 SKLEIM----FEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAE----RMRKSEEHVCQS 489
             :|:.:    |:||.:..:.:|....:          ||.:::|..:||    |..|:||...||
Human   829 -RLDFLWKNKFKKEREEIETMENLNRV----------LLENVLPAHVAEHFLARSLKNEELYHQS 882

  Fly   490 FEEVSVIFIEV---MNIYDSGSNNIQDAMQAVTTLNKVFSALDEEIISP---FVYKVETVGMVYM 548
            ::.|.|:|..:   ...|.....| ::.::.:..||::.:..|:.:..|   .|.|::|:|..||
Human   883 YDCVCVMFASIPDFKEFYTESDVN-KEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYM 946

  Fly   549 AVSG-----------APDVNPLHAEHACDLALRVMKKVKA---HALPGVAIRVGINSGPVVAGVV 599
            |.:|           .|:...:|.....:.|..::.|:.|   |:.....:|||||.|||:|||:
Human   947 AATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVI 1011

  Fly   600 GMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQKVGYKVEARGFVKVKGKGEMETYWL 664
            |.:.|:|.::|:|||.||||:|:.....||::..|:|.:|.:||....||.:.|||||:::||::
Human  1012 GAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFV 1076

Fly 665 664
Human 1077 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167
		HNOBA	218..479	CDD:400168	23/118 (19%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	64/197 (32%)
ADCY2	NP_065433.2	AC_N	<33..260	CDD:292831
		CYCc	236..439	CDD:214485
		Guanylate_cyc	281..465	CDD:278633
		DUF1053	495..599	CDD:283888
		CYCc	848..1056	CDD:214485	64/218 (29%)
		Guanylate_cyc	878..1077	CDD:278633	64/200 (32%)
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	905..922		3/17 (18%)
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	990..993		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810