DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Db and ADCY1

DIOPT Version :9

Sequence 1:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_066939.1	Gene:	ADCY1 / 107	HGNCID:	232	Length:	1119	Species:	Homo sapiens

Alignment Length:	267	Identity:	82/267 - (30%)
Similarity:	132/267 - (49%)	Gaps:	41/267 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   431 HCSKLEIMF--------EKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRKSE---- 483
            |..:::|..        :.||:|.| :||.       |.....:|::::|..:|:....|.
Human   801 HARQVDIRLRLDYLWAAQAEEERED-MEKV-------KLDNRRILFNLLPAHVAQHFLMSNPRNM 857

  Fly   484 EHVCQSFEEVSVIFIEVMNIYD----SGSNNIQDAMQAVTTLNKVFSALDEEIISPF---VYKVE 541
            :...||:.:|.|:|..:.|..|    ...||:  .::.:..||::.:..||.:...|   :.|::
Human   858 DLYYQSYSQVGVMFASIPNFNDFYIELDGNNM--GVECLRLLNEIIADFDELMEKDFYKDIEKIK 920

  Fly   542 TVGMVYMAVSG-APDVN-------PLHAEHACDLALR---VMKKVKAHALPGVAIRVGINSGPVV 595
            |:|..|||..| ||...       ..|.....|.|:.   |:.::...:.....:|||||.||||
Human   921 TIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVV 985

  Fly   596 AGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYTALKVQKVGYKVEARGFVKVKGKGEME 660
            |||:|.:.|:|.::|:|||.||||:|:.....||::......:::..|....||.|.|||||||.
Human   986 AGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRGKVSVKGKGEML 1050

  Fly   661 TYWLLEG 667
            ||: |||
Human  1051 TYF-LEG 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167
		HNOBA	218..479	CDD:400168	12/55 (22%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	66/194 (34%)
ADCY1	NP_066939.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		AC_N	<161..292	CDD:292831
		CYCc	258..453	CDD:214485
		Guanylate_cyc	294..476	CDD:278633
		Interaction with calmodulin. /evidence=ECO:0000250	493..520
		CYCc	826..1037	CDD:214485	61/219 (28%)
		Guanylate_cyc	859..1056	CDD:278633	67/199 (34%)
		Interaction with calmodulin. /evidence=ECO:0000250	1024..1047		7/22 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810