Protein Alignment Gyc89Db and gucy1a2

DIOPT Version :10

• Sequence 1: NP_650551.1
• Gene: Gyc89Db / 42002
• FlyBaseID: FBgn0038436
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: XP_073780175.1
• Gene: gucy1a2 / 100330875
• ZFINID: ZDB-GENE-121023-3
• Length: 738
• Species: Danio rerio
• Alignment Length: 708
• Identity: 165/708 - (23%)
• Similarity: 287/708 - (40%)
• Gaps: 205/708 - (28%)

  Fly     5 LYESVQHYIQQEY-GMETWRKVCQIVDCKHQSFK-------------THQIYPDKLMPDFAAALS 55
            |..:|:.|.|:|. |.|..|.:.....|..::.:             |..|    |..|| ||:.
Zfish    87 LQRTVEFYRQREISGQEFVRNLSDEQKCLFENSRCDSQTDISGILKYTATI----LGVDF-AAIR 146

  Fly    56 ASTGESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHVQMRFTYPKMKS---P 117
            ...||      .|||.|...      .::::|:.|....||....|.:...:|.:..:..|   |
Zfish   147 GRFGE------EFFGLCLEE------NERVLRALGGNLQDFFNGFDALLEHIRTSCGRRASSEAP 199

  Fly   118 SM---------QLTNMDDDGAVILYRSGRT------------GMSKYLIGQMTEVAKEFYGLDMT 161
            |.         :.||. :.||      |||            |::  :.|.:...|:..|
Zfish   200 SFLCKDAPQENEETNA-ESGA------GRTLILHCFNPDPTVGVA--MPGLIRAAARRIY----- 250

  Fly   162 AYVLESQNDICGGTAGPIKL----TEGPLTVIVKYRLDFDNR----------------DYMAKRV 206
                  |:::....|.|..|    .:|.|:.        |:.                .::.:.|
Zfish   251 ------QSEVSVEEAPPTWLHTANEDGELSA--------DSSPSSSPSPPSSSAPACLSFLIREV 301

  Fly   207 NV----IAHPSQLKMPSVDLNV----FLELFPFTIVLDHDMKITLAGEKIVETWILHNPGVNPKT 263
            :.    .:...||....:||.:    |...|||.:||..:|::...||           |:..:.
Zfish   302 HTPPTSSSRSRQLSRSPLDLRIGLSTFCRAFPFHLVLGSNMEVLQVGE-----------GLRKQA 355

  Fly   264 FIGSHILERFKCRRPKDTQIQWETILQMRTVLF--EFELIRTGHNRAAYDAALNFDFENFDEASS 326
            ....|                       ||:.|  .|||:         ...:...|:|.    .
Zfish   356 KTDPH-----------------------RTLTFSNSFELV---------SPRIPCSFQNI----L 384

  Fly   327 LNEAQAMALASAKEFSAENAKEEAAAAATSKDEIDPATGQRRHSVGLRSILLKGQMFYIKDVDSL 391
            |..:....:.:..:.|:.:.:|:.                         :.|||||.::.:.:|:
Zfish   385 LRLSTPFTIRTRPDGSSLDCREKV-------------------------MELKGQMLHLPESNSI 424

  Fly   392 IFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDE----LEKS 452
            :||.||.::.|:||.|.||:|:|:..|..:|::::.|.|  :|.:...:|   |.|:    |||:
Zfish   425 MFLGSPRVDRLEELMGRGLHLSDIPIHDATRDVILVGEQ--AKAQDGLKK---RMDKLKATLEKT 484

  Fly   453 LELADSWKRQGDELLYSMIPRPIAERMRKSEEHVCQSFEEVSVIFIEVMNIYDSGSNNI---QDA 514
            .:..:..||:..:||||:.|..:|:|:.:......:.|::|:::|.:::     |...:   ...
Zfish   485 HQALEEEKRRTVDLLYSIFPGDVAQRLWQGLPVQAKKFDDVTMLFSDIV-----GFTAVCAQCTP 544

  Fly   515 MQAVTTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLALRVMKKVKAHA 579
            ||.::.||::::..|.:.....|||:||:|..|....|.......||:....:||::|:..:...
Zfish   545 MQVISMLNELYTRFDYQCGILDVYKIETIGDAYCVAGGLHRKIDSHAKPIALMALKMMELSEEVL 609

  Fly   580 LPG---VAIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRMESSSDPWMIQLSNYT 634
            .|.   :.:|:||:||.|:|||||:.:|||||||:.|..||:.||.|.|..|.:|..|
Zfish   610 TPDGKPIKLRIGIHSGSVLAGVVGVMMPRYCLFGNNVTLASKFESGSHPRCINVSPTT 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:462233	42/193 (22%)
		HNOBA	218..479	CDD:462234	61/270 (23%)
		Nucleotidyl_cyc_III	488..665	CDD:448371	51/153 (33%)
gucy1a2	XP_073780175.1	None