DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gyc89Da and Phlpp1

DIOPT Version :9

Sequence 1:NP_001036718.1 Gene:Gyc89Da / 42001 FlyBaseID:FBgn0038435 Length:667 Species:Drosophila melanogaster
Sequence 2:NP_598582.3 Gene:Phlpp1 / 98432 MGIID:2138327 Length:1687 Species:Mus musculus


Alignment Length:274 Identity:55/274 - (20%)
Similarity:94/274 - (34%) Gaps:88/274 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   356 EIDPATGERRSSQGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLN--PHGLS 418
            |:..|.|:   .|.|::.||.|........:         :|::.:|..:||..|:..  |..|.
Mouse   684 EVPAAVGD---MQNLQTFLLDGNFLQSLPAE---------LESMHQLSYLGLSFNEFTDIPEVLE 736

  Fly   419 R-----ELVMAG-------------WQHCSKLEIMFE-KEEQRSDELE-----KSLELADSWKRQ 459
            :     :|.|||             ..|...:::... ..:..:||::     ..|:|.|:....
Mouse   737 KLTAVDKLCMAGNCVETLRLQALRRMPHIKHVDLRLNILRKLMADEVDFVQHVTQLDLRDNKLGD 801

  Fly   460 GDELLYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYDEGLNSIQGAMQTVNTLNKVFSA 524
            .|.::::.|.....||.:|....||..|                               .|...|
Mouse   802 LDAMIFNNIEVLHCERNQLVTLNVCGYF-------------------------------LKALYA 835

  Fly   525 LDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHA--EHACDLALRVMKKFKAHDMG-----DVAI 582
            ...|:....||.|... :.||.||.    |.|.:  |..|:     .:|.:..|:|     ::..
Mouse   836 SSNELAQLDVYPVPNY-LSYMDVSR----NCLESVPEWVCE-----SRKLEVLDIGHNQICELPA 890

  Fly   583 RVGINSG--PVVAG 594
            |:..||.  .::||
Mouse   891 RLFCNSSLRKLLAG 904

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc89DaNP_001036718.1 HNOB 2..161 CDD:285002
HNOBA 218..476 CDD:285003 28/145 (19%)
CYCc 457..643 CDD:214485 30/147 (20%)
Guanylate_cyc 485..662 CDD:278633 23/119 (19%)
Phlpp1NP_598582.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..96
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 230..406
PH_PHLPP-like 491..587 CDD:270131
PH 511..592 CDD:278594
LRR_RI 581..885 CDD:238064 50/253 (20%)
LRR_8 594..659 CDD:290566
LRR 1 594..615
leucine-rich repeat 597..617 CDD:275380
LRR 2 617..638
leucine-rich repeat 618..648 CDD:275380
LRR_8 647..726 CDD:290566 12/53 (23%)
LRR 3 648..669
LRR 4 671..692 3/10 (30%)
leucine-rich repeat 672..694 CDD:275380 3/12 (25%)
LRR 5 694..715 5/29 (17%)
leucine-rich repeat 695..717 CDD:275380 5/30 (17%)
LRR 6 717..739 6/21 (29%)
leucine-rich repeat 718..740 CDD:275380 6/21 (29%)
LRR 7 740..760 4/19 (21%)
leucine-rich repeat 741..764 CDD:275380 4/22 (18%)
LRR 8 764..785 3/20 (15%)
LRR_RI 768..1030 CDD:238064 35/178 (20%)
leucine-rich repeat 768..788 CDD:275380 2/19 (11%)
LRR 9 788..809 4/20 (20%)
leucine-rich repeat 789..809 CDD:275380 4/19 (21%)
leucine-rich repeat 810..851 CDD:275380 13/71 (18%)
LRR 10 829..850 7/51 (14%)
LRR 11 851..872 8/30 (27%)
leucine-rich repeat 852..874 CDD:275380 8/30 (27%)
LRR 12 874..895 4/20 (20%)
leucine-rich repeat 875..897 CDD:275380 4/21 (19%)
LRR_8 896..954 CDD:290566 3/9 (33%)
LRR 13 897..918 2/8 (25%)
leucine-rich repeat 898..919 CDD:275380 2/7 (29%)
LRR 14 919..940
leucine-rich repeat 920..943 CDD:275380
LRR 15 943..964
leucine-rich repeat 944..967 CDD:275380
LRR 16 969..989
LRR_8 970..1028 CDD:290566
leucine-rich repeat 970..993 CDD:275380
LRR 17 993..1014
leucine-rich repeat 994..1017 CDD:275380
LRR 18 1017..1038
LRR 19 1040..1061
LRR 20 1062..1083
leucine-rich repeat 1063..1085 CDD:275380
LRR 21 1085..1106
PP2Cc 1124..1376 CDD:214625
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1414..1465
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1604..1687
PDZ-binding 1685..1687
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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