DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and CYR1

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_012529.3	Gene:	CYR1 / 853452	SGDID:	S000003542	Length:	2026	Species:	Saccharomyces cerevisiae

Alignment Length:	620	Identity:	114/620 - (18%)
Similarity:	203/620 - (32%)	Gaps:	230/620 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 YDK-MIRSTGRYFCDFLQSIDNIHLIMRFTYPKMKSPSMQLTNMDDNGAVILYRSSRTGMSKYLI 145
            ||| :||...||..   ::.|||...:||::.::......:.|..||||.:    :....:..|.
Yeast  1413 YDKILIRQLERYGD---ETDDNIKTALRFSFLQLNKEINGMLNSVDNGADV----ANLSYADLLS 1470

  Fly   146 GQMTEVAREFYGLEIKAYVIESQNDISGGTAGPIKLTDGPLTVIVKYRLDFDNREYMAKRVNTEA 210
            |..:.|      :.|:...:.:.|  .|.....:...:|....:.|..|.....||...|: :..
Yeast  1471 GACSTV------IYIRGKKLFAAN--LGDCMAILSKNNGDYQTLTKQHLPTKREEYERIRI-SGG 1526

  Fly   211 HPSQLKMPTVKLDV-----FLDLFPFTFVLNHDMKI---THAGEKIVETWIMHNPGANPKSFIGT 267
            :.:..|:..| :||     |.||.|.... :.|:.:   |.|.|.::               :.|
Yeast  1527 YVNNGKLDGV-VDVSRAVGFFDLLPHIHA-SPDISVVTLTKADEMLI---------------VAT 1574

  Fly   268 H----VMDLFQCRRPKDTTID---WDTLIQMRAVLFEFELIRTGHNRAAYDAVLNMD------FE 319
            |    .||:       ||..|   .::...:||..   ||   ..:..||....|:.      :|
Yeast  1575 HKLWEYMDV-------DTVCDIARENSTDPLRAAA---EL---KDHAMAYGCTENITILCLALYE 1626

  Fly   320 NYDEMD---LNEAQTMALAKAQEFSESHPVDDDESAR--EDEIDPATGERRSSQGLRSILLKGQM 379
            |..:.:   ||:...|......|         |.:.|  :.||.|.||              ...
Yeast  1627 NIQQQNRFTLNKNSLMTRRSTFE---------DTTLRRLQPEISPPTG--------------NLA 1668

  Fly   380 FYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSD 444
            ....|:.|..||.                  :|.|:.:...:                  :..:|
Yeast  1669 MVFTDIKSSTFLW------------------ELFPNAMRTAI------------------KTHND 1697

  Fly   445 ELEKSLELADSW--KRQGDELLYSMIPRP-------IAERMRLSEEQVCQSFEEVSVIFLEVMNV 500
            .:.:.|.:...:  |.:||..:.: .|.|       ::.:::|.:.|
Yeast  1698 IMRRQLRIYGGYEVKTEGDAFMVA-FPTPTSGLTWCLSVQLKLLDAQ------------------ 1743

  Fly   501 YDEGLNSIQGAMQTVNTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLA 565
            :.|.:.|:|...|..:....:                     :|..:|
Yeast  1744 WPEEITSVQDGCQVTDRNGNI---------------------IYQGLS----------------- 1770

  Fly   566 LRVMKKFKAHDMGDVAIRVGINSG-PV-VAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLS 628
                            :|:||:.| || ...:|.|::.   ..|..||.|:|::..:|..:|.:|
Yeast  1771 ----------------VRMGIHWGCPVPELDLVTQRMD---YLGPMVNKAARVQGVADGGQIAMS 1816

  Fly   629 K--YTG-DKVRQVGYKVESRGTVQVKGKGDM-ETY 659
            .  |:. :|:.:...:|       ||||..: |.|
Yeast  1817 SDFYSEFNKIMKYHERV-------VKGKESLKEVY 1844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	20/79 (25%)
		HNOBA	218..476	CDD:285003	51/292 (17%)
		CYCc	457..643	CDD:214485	31/197 (16%)
		Guanylate_cyc	485..662	CDD:278633	31/181 (17%)
CYR1	NP_012529.3	Ad_cyc_g-alpha	368..418	CDD:369912
		RA_PHLPP_like	678..776	CDD:340473
		PLN00113	792..>1273	CDD:215061
		leucine-rich repeat	796..817	CDD:275380
		leucine-rich repeat	818..839	CDD:275380
		leucine-rich repeat	840..864	CDD:275380
		leucine-rich repeat	865..887	CDD:275380
		leucine-rich repeat	888..910	CDD:275380
		leucine-rich repeat	911..933	CDD:275380
		leucine-rich repeat	934..956	CDD:275380
		leucine-rich repeat	957..978	CDD:275380
		leucine-rich repeat	979..1018	CDD:275380
		leucine-rich repeat	1019..1041	CDD:275380
		leucine-rich repeat	1042..1065	CDD:275380
		leucine-rich repeat	1066..1088	CDD:275380
		leucine-rich repeat	1089..1111	CDD:275380
		leucine-rich repeat	1167..1187	CDD:275380
		leucine-rich repeat	1191..1211	CDD:275380
		leucine-rich repeat	1236..1258	CDD:275380
		leucine-rich repeat	1259..1287	CDD:275380
		PP2C	1374..1617	CDD:395385	54/249 (22%)
		CYCc	1613..1825	CDD:214485	52/346 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900