DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and Adcy2

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_112269.2	Gene:	Adcy2 / 81636	RGDID:	619965	Length:	1095	Species:	Rattus norvegicus

Alignment Length:	462	Identity:	114/462 - (24%)
Similarity:	195/462 - (42%)	Gaps:	108/462 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 LFQCRRPKDTTIDWDTLIQMRAVLFEFELIRTGHNRAAYDAVLNMDFENYDEMDLNEAQTMALAK 336
            |.||.:...|::.|  |::...::......|..........:|.|...|...:..:|..|:..|.
  Rat   655 LLQCSKKASTSLMW--LLKSSGIIANRPWPRISLTIVTTAIILTMAVFNMFFLSNSEETTLPTAN 717

  Fly   337 AQEFSESHPVDDDESAREDEIDPATGERRSSQGLRSILLKGQMFYIK------------------ 383
            ....:.|.|   |..|                   |||....:|::.
  Rat   718 TSNANVSVP---DNQA-------------------SILHARNLFFLPYFIYSCILGLISCSVFLR 760

  Fly   384 ---DVDSLIFLCSPLIENLDELH-----------------GIGLYLNDLNPHGLS---RELVMAG 425
               ::..||.:.:.:..|...||                 ||...|..:....||   ..|::.|
  Rat   761 VNYELKMLIMMVALVGYNTILLHTHAHVLDAYSQVLFQRPGIWKDLKTMGSVSLSIFFITLLVLG 825

  Fly   426 WQ---HCSKLEIM----FEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAE----RMRLS 479
            .|   :| :|:.:    |:||.:..:.:|....:          ||.:::|..:||    |...:
  Rat   826 RQSEYYC-RLDFLWKNKFKKEREEIETMENLNRV----------LLENVLPAHVAEHFLARSLKN 879

  Fly   480 EEQVCQSFEEVSVIFLEV---MNVYDEGLNSIQGAMQTVNTLNKVFSALDEEIISP---FVYKVE 538
            ||...||::.|.|:|..:   ...|.|...:.:| ::.:..||::.:..|:.:..|   .|.|::
  Rat   880 EELYHQSYDCVCVMFASIPDFKEFYTESDVNKEG-LECLRLLNEIIADFDDLLSKPKFSGVEKIK 943

  Fly   539 TVGMVYMAVSG-----------APDVNPLHAEHACDLALRVMKKFKA---HDMGDVAIRVGINSG 589
            |:|..|||.:|           .|:...:|.....:.|..::.|..|   |...|..:|||||.|
  Rat   944 TIGSTYMAATGLSAIPSQEHAQEPERQYMHIGTMVEFAYALVGKLDAINKHSFNDFKLRVGINHG 1008

  Fly   590 PVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGDKVRQVGYKVESRGTVQVKGKG 654
            ||:|||:|.:.|:|.::|:|||.||||:|:....|||:::.|...::.:||....||.:.|||||
  Rat  1009 PVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKG 1073

  Fly   655 DMETYWL 661
            |::||::
  Rat  1074 DLKTYFV 1080

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002
		HNOBA	218..476	CDD:285003	45/255 (18%)
		CYCc	457..643	CDD:214485	64/209 (31%)
		Guanylate_cyc	485..662	CDD:278633	66/197 (34%)
Adcy2	NP_112269.2	AC_N	<37..264	CDD:318454
		Guanylate_cyc	285..469	CDD:306677
		DUF1053	499..603	CDD:399378
		Guanylate_cyc	882..1081	CDD:306677	66/200 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810