DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and si:dkey-37g12.1

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	XP_021333677.1	Gene:	si:dkey-37g12.1 / 796669	ZFINID:	ZDB-GENE-090312-145	Length:	882	Species:	Danio rerio

Alignment Length:	473	Identity:	130/473 - (27%)
Similarity:	213/473 - (45%)	Gaps:	117/473 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 VMDLFQCRRPKDTTIDWDTLIQMRAVLFEFELIRTGHNRAAYDAVLNMDFENYDEMD----LNEA 329
            :.|:.|....|   :||         .|:|.|:        .|.|..||:.::..:.    |:.:
Zfish   444 LQDILQNESIK---LDW---------TFKFSLM--------LDIVKGMDYLHHSPLQYHGHLSSS 488

  Fly   330 QTMA----LAKAQEF---------SESHPVDDDESA---REDEI----DPATGERRSSQG----- 369
            ..:.    :.|..:|         :|..|..|..:|   |..|:    .||.|.::....
Zfish   489 SCVVDSRFVLKVTDFGLNSVRRLDTEQSPGSDPWTALLWRAPELLRQSIPANGTQKGDVYSFAII 553

  Fly   370 LRSILLKGQMFYI-------KDVDSLIFL--CSP---------LIENLDEL-------------- 402
            .:.::.:...|||       :::...:..  |||         .:|.|:.|
Zfish   554 AQEVVYRRGPFYIPNSHFSPREIVERVRAGGCSPSRPYIDRAECVEELESLVVSCWRETPAERPD 618

  Fly   403 -HGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDEL-----EKSLELADSWKRQGD 461
             ..|...:...:|||:|..:          |:.:..:.||.:..|     |::.||.:. |::.:
Zfish   619 FSYIRTAIKKNSPHGVSENI----------LDDLLSRMEQYACNLEEIVSERTAELQEE-KKRAE 672

  Fly   462 ELLYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYDEGLNSIQGA---MQTVNTLNKVFS 523
            .||..|:||.:|.::...:....::::.|::.|.::     ||..::..:   ||.||.||.:::
Zfish   673 GLLTQMLPRSVASQLIAGKTVRAETYDCVTIYFSDI-----EGFTAMSASLTPMQVVNVLNDLYT 732

  Fly   524 ALDEEIISPFVYKVETVGMVYMAVSGAPDVN-PLHAEHACDLALRVMKKFKAHDMGDV-----AI 582
            ..|..|....||||||:|..||.|||.|..| ..||:....::|.:::..::.....|     .:
Zfish   733 YFDNIIDYHNVYKVETIGDAYMVVSGLPIRNGDDHAKEIARMSLAIVQGLRSFHSPHVPEQQLRV 797

  Fly   583 RVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTG---DKVRQVGYKVES 644
            |:|::|||.||||||.|:||||||||||||||||||...|.||.:|..|.   |..|  .::.|.
Zfish   798 RIGVHSGPCVAGVVGLKMPRYCLFGDTVNTASRMESYGLPLKIHVSSSTKSLLDTFR--NFRCEL 860

  Fly   645 RGTVQVKGKGDMETYWLL 662
            ||.:.:||||.:.|:|||
Zfish   861 RGDIHIKGKGWVRTFWLL 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002
		HNOBA	218..476	CDD:285003	52/273 (19%)
		CYCc	457..643	CDD:214485	74/197 (38%)
		Guanylate_cyc	485..662	CDD:278633	76/188 (40%)
si:dkey-37g12.1	XP_021333677.1	Periplasmic_Binding_Protein_Type_1	<59..258	CDD:324556
		PKc_like	355..628	CDD:328722	34/203 (17%)
		HNOBA	<641..687	CDD:311573	13/46 (28%)
		CYCc	666..850	CDD:214485	72/189 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810