DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and Gucy2g

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001074545.1	Gene:	Gucy2g / 73707	MGIID:	106025	Length:	1100	Species:	Mus musculus

Alignment Length:	538	Identity:	152/538 - (28%)
Similarity:	233/538 - (43%)	Gaps:	136/538 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 LKMPTVKLDVFL-------DLFPFTFVLNHDMKITHAGEKIVETWIMHNPGANPKSFIGTHVMDL 272
            :|.|||:.:|.|       ::.||..|......|.     ||..:....              .|
Mouse   595 VKKPTVRREVCLMCELKHENIVPFFGVCTEPPNIC-----IVTQYCKKG--------------SL 640

  Fly   273 FQCRRPKDTTIDW-----------------------------------DTLIQMRAVLFEFELIR 302
            ....|..|..|||                                   |:.:|::...|.....:
Mouse   641 QDVMRNSDHEIDWIFKLSFAYDIVNGLLFLHGSPLRSHGNLKPSNCLVDSHMQLKLSGFGLWEFK 705

  Fly   303 TGHNRAAYDAVLNMDFENYDE--------MDLNEAQTMALAKAQEFS-----------ESH-PVD 347
            .|....:|    |.:..::.|        :.|.|:......:...:|           ::| |.:
Mouse   706 HGSTWRSY----NQEATDHSELYWTAPELLRLRESPCSGTPQGDVYSFAILLRDLIHQQAHGPFE 766

  Fly   348 DDESAREDEI----DPATGERRSSQGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELH----G 404
            |.|:|.|:.|    ||     |:...||..||:.     |....::.|.....:...||.    .
Mouse   767 DLEAAPEEIISRIKDP-----RAPVPLRPSLLED-----KGDGRIVALVRECWDESPELRPIFPS 821

  Fly   405 IGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLE------LADSWKRQGDEL 463
            |...|.:.:|.|           |.|.|:.|..|.|..::.||:.:|      :|:  ||:.::|
Mouse   822 IKKTLREASPRG-----------HVSILDSMMGKLETYANHLEEVVEERTRELVAE--KRKVEKL 873

  Fly   464 LYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYDEGLNSIQGAMQTVNTLNKVFSALDEE 528
            |.:|:|..:.|::...:....:.||.|::.|.:::..  ..|.|:...:|.|..||.::|..|..
Mouse   874 LSTMLPSFVGEQLIAGKSVEPEHFESVTIFFSDIVGF--TKLCSLSSPLQVVKLLNDLYSLFDHT 936

  Fly   529 IISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLA------LRVMKKFKAHDMGD--VAIRVG 585
            |.|..||||||:|..||..||.|..|  .|:||.::|      |.|...|:...|.:  :.:|:|
Mouse   937 IQSHDVYKVETIGDAYMVASGLPIRN--GAQHADEIATMALHLLSVTTHFQIGHMPEERLKLRIG 999

  Fly   586 INSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYT-GDKVRQVGYKVESRGTVQ 649
            :::|||||||||..:|||||||||||.||||||||.|.:|.:|:.| |..:...||.::.|||:.
Mouse  1000 LHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLRIHVSQSTAGALLAAGGYHLQKRGTIS 1064

  Fly   650 VKGKGDMETYWLLEGPEG 667
            |||||:..|:| |:|.:|
Mouse  1065 VKGKGEQTTFW-LKGKDG 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002
		HNOBA	218..476	CDD:285003	66/333 (20%)
		CYCc	457..643	CDD:214485	79/194 (41%)
		Guanylate_cyc	485..662	CDD:278633	82/185 (44%)
Gucy2g	NP_001074545.1	PBP1_GC_G-like	47..436	CDD:380595
		PK_GC	555..829	CDD:270894	48/266 (18%)
		CYCc	865..1055	CDD:214485	78/195 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810