DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gyc89Da and Adcy5

DIOPT Version :9

Sequence 1:NP_001036718.1 Gene:Gyc89Da / 42001 FlyBaseID:FBgn0038435 Length:667 Species:Drosophila melanogaster
Sequence 2:NP_072122.2 Gene:Adcy5 / 64532 RGDID:71014 Length:1262 Species:Rattus norvegicus


Alignment Length:540 Identity:135/540 - (25%)
Similarity:232/540 - (42%) Gaps:147/540 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   179 IKLTDGPLTVIVKYRLDFDNREYMAKRVNTEAHPSQLKMPTVKLDVFLDLFPFTFVLN------- 236
            :||...||..:.:            |.|.::.:.:.:.:.|:.| |||..|...|:.|       
  Rat   814 VKLFPTPLQTLSR------------KIVRSKKNSTLVGVFTITL-VFLSAFVNMFMCNSKNLVGC 865

  Fly   237 ----HDMKIT-----HAGEKIV------ETWIMHNPGAN---PKSFIGTHVMDLFQCRRPKDTTI 283
                |::.:.     |..|...      |.....:|.:|   |:.|..:.::.|..|        
  Rat   866 LAEEHNITVNQVNACHVMESAFNYSLGDEQGFCGSPQSNCNFPEYFTYSVLLSLLAC-------- 922

  Fly   284 DWDTLIQMRAV-----LFEFELIRTGHNRAAYDAVLNMD----FENYDEMDLNEAQTMALAKAQE 339
              ...:|:..:     :...|||        |..::.:.    |:|        |..:..|.|.:
  Rat   923 --SVFLQISCIGKLVLMLAIELI--------YVLIVEVPGVTLFDN--------ADLLVTANAID 969

  Fly   340 FSESHPVDDDESAREDEIDPATGERRSSQGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHG 404
            ||.:                  |..:..:....:.||              :.:|:|.::..|  
  Rat   970 FSNN------------------GTSQCPEHATKVALK--------------VVTPIIISVFVL-- 1000

  Fly   405 IGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIP 469
             .|||:.......:|...:  |    ||:...||||.  :||:       ::.|:   ||::::|
  Rat  1001 -ALYLHAQQVESTARLDFL--W----KLQATEEKEEM--EELQ-------AYNRR---LLHNILP 1046

  Fly   470 RPIA----ERMRLSEEQVCQSFEEVSVIFLEVMN---VYDEGLNSIQGAMQTVNTLNKVFSALDE 527
            :.:|    .|.|.::|...||.|.|:|:|..:.|   .|.| |.:....::.:..||::.:..| 
  Rat  1047 KDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVE-LEANNEGVECLRLLNEIIADFD- 1109

  Fly   528 EIISPFVY----KVETVGMVYMAVSGAPD-----VNPLHAEHACDLALRVMKKFK---AHDMGDV 580
            ||||...:    |::|:|..|||.||..|     ....|.:...|.|:::|.:.|   .|...:.
  Rat  1110 EIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKAGKTHIKALADFAMKLMDQMKYINEHSFNNF 1174

  Fly   581 AIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGDKVRQVGYKVESR 645
            .:::|:|.|||||||:|.:.|:|.::|:|||.||||:|:..|.:||::......:....|::|.|
  Rat  1175 QMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECR 1239

  Fly   646 GTVQVKGKGDMETYWLLEGP 665
            |.|:|||||:|.||:|..||
  Rat  1240 GVVKVKGKGEMMTYFLNGGP 1259

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc89DaNP_001036718.1 HNOB 2..161 CDD:285002
HNOBA 218..476 CDD:285003 54/295 (18%)
CYCc 457..643 CDD:214485 65/204 (32%)
Guanylate_cyc 485..662 CDD:278633 69/191 (36%)
Adcy5NP_072122.2 AC_N 1..459 CDD:318454
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..196
Guanylate_cyc 461..634 CDD:306677
DUF1053 669..761 CDD:399378
Guanylate_cyc 1063..1257 CDD:306677 70/195 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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