Protein Alignment Gyc89Da and Gucy1a1

DIOPT Version :9

• Sequence 1: NP_001036718.1
• Gene: Gyc89Da / 42001
• FlyBaseID: FBgn0038435
• Length: 667
• Species: Drosophila melanogaster
• Sequence 2: NP_001343916.1
• Gene: Gucy1a1 / 60596
• MGIID: 1926562
• Length: 691
• Species: Mus musculus
• Alignment Length: 615
• Identity: 151/615 - (24%)
• Similarity: 255/615 - (41%)
• Gaps: 157/615 - (25%)

  Fly    52 EALSACTGES-FDFCMNFFGRCFVRFFSNFGYDK---MIRSTGRYFCDFLQSIDNI-----HLIM 107
            |||....||. |..|                |::   ::...|....|||.|...:     |...
Mouse   130 EALKDSLGEELFKIC----------------YEEDEHILGVVGGTLKDFLNSFSTLLKQSSHCQE 178

  Fly   108 RFTYPKMKSPSMQLTNMDDNGAVILYRSSRTGMSKYLIGQMTEVAREFYGLEIKAYVIESQNDIS 172
            .....:::..|:...:.|.:...:.|...:...:..|.|.:...||..|         ||..::|
Mouse   179 AERRGRLEDASILCLDKDQDFLNVYYFFPKRTTALLLPGIIKAAARILY---------ESHVEVS 234

  Fly   173 GGTAGPIKLTDGPLTVIVKYRLDFDNREYMAKRVNTEA---------HPSQLKMPTVKLDVFLDL 228
              ...|...:|         ..:|.|:.|:...|:.::         ..|.|.:|.   .:|...
Mouse   235 --LMPPCFRSD---------CTEFVNQPYLLYSVHVKSTKPSLSPGKPQSSLVIPA---SLFCKT 285

  Fly   229 FPFTFVLNHDMKITHAGEKIVETWIMHNPGANPKSFIG-THVMDLFQCRRPKDTTIDWDTLIQMR 292
            |||.|:|:.|:.|...|..|...       .|.:.|.| .:..:.|:...||
Mouse   286 FPFHFMLDRDLAILQLGNGIRRL-------VNKRDFQGKPNFEEFFEILTPK------------- 330

  Fly   293 AVLFEFELIRTGHNRAAYDAVLNMDFENYDEMDLNEAQTMALAKAQEFSESHPVDDDESAREDEI 357
             :...|..|.|         :|||.|               :.:.:.:..|
Mouse   331 -INQTFSGIMT---------MLNMQF---------------VIRVRRWDNS-------------- 356

  Fly   358 DPATGERRSSQGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELV 422
                 .::||   |.:.|||||.||.:..:::||.||.::.|::..|.||||:|:..|...|::|
Mouse   357 -----VKKSS---RVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVV 413

  Fly   423 MAGWQHCSKLEIMFEKEEQRSDELEKSLELA----DSWKRQGDELLYSMIPRPIAERMRLSEEQV 483
            :.|.|..::     :..::|..:|:.:||.|    :..|::..:||.|:.|..:|:::...:...
Mouse   414 LIGEQARAQ-----DGLKKRLGKLKATLEHAHQALEEEKKRTVDLLCSIFPSEVAQQLWQGQIVQ 473

  Fly   484 CQSFEEVSVIFLEVMNVYDEGLNSI---QGAMQTVNTLNKVFSALDEEIISPFVYKVETVGMVYM 545
            .:.|.||:::|.:::     |..:|   ...:|.:..||.:::..|::.....||||||:|..|.
Mouse   474 AKKFSEVTMLFSDIV-----GFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYC 533

  Fly   546 AVSGAPDVNPLHAE---HACDLALRVMKKFKAHD-----MGD-VAIRVGINSGPVVAGVVGQKVP 601
            ...|      ||.|   ||..:||..:|..:..:     .|: :.:|:|::||.|.|||||.|:|
Mouse   534 VAGG------LHRESDTHAVQIALMALKMMELSNEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592

  Fly   602 RYCLFGDTVNTASRMESSSDPWKIQLSKYT 631
            ||||||:.|..|::.||.|.|.||.:|..|
Mouse   593 RYCLFGNNVTLANKFESCSVPRKINVSPTT 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	22/117 (19%)
		HNOBA	218..476	CDD:285003	62/262 (24%)
		CYCc	457..643	CDD:214485	62/187 (33%)
		Guanylate_cyc	485..662	CDD:278633	56/159 (35%)
Gucy1a1	NP_001343916.1	HNOBA	277..466	CDD:311573	62/263 (24%)
		Guanylate_cyc	472..643	CDD:306677	56/162 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810