DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gyc89Da and Phlpp1

DIOPT Version :9

Sequence 1:NP_001036718.1 Gene:Gyc89Da / 42001 FlyBaseID:FBgn0038435 Length:667 Species:Drosophila melanogaster
Sequence 2:XP_038946976.1 Gene:Phlpp1 / 59265 RGDID:621308 Length:1718 Species:Rattus norvegicus


Alignment Length:580 Identity:114/580 - (19%)
Similarity:194/580 - (33%) Gaps:207/580 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 CFVRFFS----NFGYDKMIRSTGRYFCDFLQSIDNIHLIMRFTYPKMKSPSMQL-TNMDDNGAVI 131
            |.:||::    :.|..:.|:.:|.|                    .::...||| .|......||
  Rat   482 CLIRFYAGKPHSTGSSERIQLSGMY--------------------NVRKGKMQLPVNRWTRRQVI 526

  Fly   132 L---------YRSSRTGMSKY--LIGQMTEVAREFYGLEIKAYVIESQNDISGGTAGPIKLTDGP 185
            |         .:.|.:|....  |||...|        |:|.:    |:.::..::||...|   
  Rat   527 LCGTCLIVSSVKDSSSGKMHVLPLIGGKVE--------EVKKH----QHCLAFSSSGPQSQT--- 576

  Fly   186 LTVIVKYRLDFDN-REYM--AKRVNTEAHPSQLKMPTVKLD-VFLDLFPFTFVLNHDMKITHAGE 246
                  |.:.||. .||:  .::|:..|  || ::.:|.|. ..|:..|.....:.|  :||...
  Rat   577 ------YYICFDTFTEYLRWLRQVSKVA--SQ-RISSVDLSCCSLEHLPANLFYSQD--LTHLNL 630

  Fly   247 KIVETWIMHNPGANPKSFIGTHVMDLFQCRRPKDTTIDWDTLIQMRAVLFEFELIRTGHNRAAYD 311
            |  :.::..||.......:|    :|.:..:.|...:.                  ..|..|...
  Rat   631 K--QNFLRQNPSLPAARGLG----ELQRFTKLKSLNLS------------------NNHLGAFPS 671

  Fly   312 AVLNMDFENYDEMDLNEAQTMALAKAQEFSESHPVDDDESAREDEIDPATGERRSSQGLRSILLK 376
            ||.::             .|:|     |.:.|     ..:.|  |:..|.|   :.|.|::.||.
  Rat   672 AVCSI-------------PTLA-----ELNVS-----CNALR--EVPAAVG---AMQNLQTFLLD 708

  Fly   377 GQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLN--PHGLSR-----ELVMAGWQHCS---- 430
            |........:         :||:.:|..:||..|:..  |..|.:     :|.|||  :|.    
  Rat   709 GNFLQSLPAE---------LENMHQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMAG--NCMETLR 762

  Fly   431 ---------------KLEIMFEKEEQRSDELE--KSLELADSWKRQGDELLYSMIPRPIAERMRL 478
                           :|.|:.:......|.|:  ..|:|.|:.....|.::::.|.....||.:|
  Rat   763 LQALRRMPHIKHVDLRLNILRKLITDEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQL 827

  Fly   479 SEEQVCQSFEEVSVIFLEVMNVYDEGLNSIQGAMQTVNTLNKVFSALDEEIISPFVYKVETVGMV 543
            ....:|..|                               .|...|...|::...||.|... :.
  Rat   828 VTLNICGYF-------------------------------LKALYASSNELVQLDVYPVPNY-LS 860

  Fly   544 YMAVSGAPDVNPLHA--EHACDLALRVMKKFKAHDMG-----DVAIRVGINSG--PVVAG 594
            ||.||.    |.|.:  |..|:     .:|.:..|:|     ::..|:..||.  .::||
  Rat   861 YMDVSR----NCLESVPEWVCE-----SRKLEVLDIGHNQICELPARLFCNSSLRKLLAG 911

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc89DaNP_001036718.1 HNOB 2..161 CDD:285002 21/104 (20%)
HNOBA 218..476 CDD:285003 53/286 (19%)
CYCc 457..643 CDD:214485 29/147 (20%)
Guanylate_cyc 485..662 CDD:278633 23/119 (19%)
Phlpp1XP_038946976.1 Ubiquitin_like_fold 176..>224 CDD:421700
PHA03247 <237..443 CDD:223021
RA_PHLPP1 <424..491 CDD:340760 3/8 (38%)
PH_PHLPP-like 498..594 CDD:270131 27/136 (20%)
PLN00113 602..>1109 CDD:215061 79/416 (19%)
leucine-rich repeat 604..624 CDD:275380 4/19 (21%)
leucine-rich repeat 625..655 CDD:275380 7/35 (20%)
leucine-rich repeat 679..701 CDD:275380 7/36 (19%)
leucine-rich repeat 702..724 CDD:275380 6/30 (20%)
leucine-rich repeat 725..771 CDD:275380 11/47 (23%)
leucine-rich repeat 772..795 CDD:275380 4/22 (18%)
leucine-rich repeat 796..816 CDD:275380 4/19 (21%)
leucine-rich repeat 817..858 CDD:275380 12/71 (17%)
leucine-rich repeat 859..881 CDD:275380 8/30 (27%)
leucine-rich repeat 882..904 CDD:275380 4/21 (19%)
leucine-rich repeat 905..926 CDD:275380 2/7 (29%)
leucine-rich repeat 927..950 CDD:275380
leucine-rich repeat 951..974 CDD:275380
leucine-rich repeat 977..1000 CDD:275380
leucine-rich repeat 1001..1024 CDD:275380
leucine-rich repeat 1067..1112 CDD:275380
PP2Cc 1151..1403 CDD:214625
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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