DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and CG34357

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	138/543 - (25%)
Similarity:	233/543 - (42%)	Gaps:	146/543 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 DMKITHAGEKIVETWIMHNPGANPKSFIGTHVMDLFQC-----RRPKDTTIDWDTLIQMRAVLFE 297
            ||:..:.|:.:.    :.....|..:.:.|..|||...     ....:..|.|.:.....|::|:
  Fly   780 DMRARYNGDLVQ----LKEVNINGSAELRTKAMDLLVMAHGLRHENINPLIGWLSDPNRTAMVFD 840

  Fly   298 FELIRTGHNRAAYDAVLNMDFENYDEMDLNEAQTMA----LAKAQEFSESHP--VDDDESAREDE 356
            :      .:|.:...||.|     ||:.|:.:..::    |.:...:..:.|  |....::|...
  Fly   841 Y------CSRGSLQDVLIM-----DEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGALTSRNCV 894

  Fly   357 IDPATGERRSSQGLRSILLKGQMFY--------IKDVDSLIFLCSPLIENL-----DELHG---I 405
            :|.....:.:..||.|       ||        .:....|::....|:.|:     ...||   :
  Fly   895 VDARWVLKITDYGLNS-------FYESQGLPPRTRSAKELLWTAPELLRNMKLHQHHHQHGRIQL 952

  Fly   406 GLYLNDLNPHG-LSRELVMAGWQHC------------------------SK-------------- 431
            |..|.|:...| :.:|:|:.|..:|                        ||
  Fly   953 GTQLGDVYSFGIIMQEVVVRGEPYCMLSLSPEEIIVKIKKPPPLIRPSVSKGAAPPEAINIMRQC 1017

  Fly   432 -----------------------------LEIMFEKEEQRSDELEKSL----ELADSWKRQGDEL 463
                                         ::.||:..|:.|:.||:.:    |..|..:::.::|
  Fly  1018 WAEQPDMRPDFNSVYERFKMLNHGRKVNFVDTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQL 1082

  Fly   464 LYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYDEGLNSIQ---GAMQTVNTLNKVFSAL 525
            |..|:|..:||::::......:.|.:|::.|.:::     |..:|.   ..:|.|:.||.:::..
  Fly  1083 LNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIV-----GFTTIAAHCSPVQVVDLLNDLYTIF 1142

  Fly   526 DEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLALRVMKKFKAHDMG----------DV 580
            |..|.:..||||||:|..||.|||.|...|.|||....:||.::     |..|          .:
  Fly  1143 DATINAYNVYKVETIGDAYMVVSGLPVKIPDHAEQIATMALDLL-----HQSGRFNVKHLPGVPL 1202

  Fly   581 AIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGDKV-RQVGYKVES 644
            .:|:|:::||..|||||..:||||||||||||||||||:...|:|.:|:.|.|:: .:.||.:|.
  Fly  1203 QLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDARGGYAIEP 1267

  Fly   645 RGTVQVKGKGDMETYWLLEGPEG 667
            ||.:.:||||.|.|:||| |.:|
  Fly  1268 RGLIDIKGKGMMNTFWLL-GKKG 1289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002
		HNOBA	218..476	CDD:285003	58/336 (17%)
		CYCc	457..643	CDD:214485	72/199 (36%)
		Guanylate_cyc	485..662	CDD:278633	76/190 (40%)
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	44/282 (16%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	72/201 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810