DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and gucy2ca

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	XP_009297342.1	Gene:	gucy2ca / 572052	ZFINID:	ZDB-GENE-091118-67	Length:	1025	Species:	Danio rerio

Alignment Length:	700	Identity:	161/700 - (23%)
Similarity:	259/700 - (37%)	Gaps:	186/700 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 GYDKM------------IRSTGRYFCDFLQSIDNIHLIMRFTYPKMKSPSMQLTNMDDNGAVILY 133
            ||.|:            :.:||.|....|.|.|.   ....|..|..||.:......      |.
Zfish   316 GYYKLDSSGDRDLNLSVVYTTGSYKYRTLFSFDT---SQNRTKVKDSSPDLPWDRSQ------LP 371

  Fly   134 RSSRTGMSKYLIGQMTEVAREFYGLEIK-----AYVIESQN-----------DISGGTAGPIKLT 182
            |...|||      ::.|:.....||.:.     |:::..||           .||.....|
Zfish   372 RDKHTGM------EIQEIMMIVLGLSVVLATVIAFILYRQNRRVRFDQKKWSHISSSLITP---- 426

  Fly   183 DGPLTVIVKYRLDFDNREYMAKRVNTE--AHPSQL-------KMPTVKLDVFLDLFPFTFVLNHD 238
                       ||...|.|::..::.:  ...|.|       |.|.:..:          :.|.|
Zfish   427 -----------LDDKERNYISLTIDEDKKGDNSSLIRKGRYDKKPVILKE----------LRNTD 470

  Fly   239 MKITHAGEKIVETWIMHNPGANPKSFIGTHVMDLFQCRRPKDTTIDWDTLIQMRAVLFEFELIRT 303
            ...|. .::|....::.....|...|.||   ..|.|                 .|...||....
Zfish   471 GNFTD-DQRIELNALLRIDYYNLTKFYGT---VRFDC-----------------GVFGVFEFCER 514

  Fly   304 GHNRAAYDAVLNMDFENYDEMDLNEAQTMALAKAQEFSESHPVDDDESAREDE--IDPATGERRS 366
            |..|...|..::....::.:::...:....:||...:..|..|......:...  :|.....:.:
Zfish   515 GSLRYVLDDKISYPDASFMDLEFRISVMYDIAKGMSYLHSSNVGVHGRLKSTNCVVDNRMVVKIT 579

  Fly   367 SQGLRSIL-------------------LKGQMFYIKDVDSLIFL---------CSPLIENL---D 400
            ..|..:||                   .||.::....:...|.|         ||.:.|.|   .
Zfish   580 DFGCNTILSPGKDLWTAPEHMRVEGISQKGDVYSFAIISQEIILRKSPFHTSCCSDMAEKLYLVQ 644

  Fly   401 ELHGIGLYLNDLNPHGLSRE------LVMAGWQ---------------------------HCSKL 432
            ...|..::..||:..|:...      |:.:.|:                           :.|.:
Zfish   645 YPRGPNVFRPDLSFEGVGETEAELFVLIKSCWEEDPEKRPDFKRIEGALGKIFSNLHNQANASYM 709

  Fly   433 EIMFEKEEQRSDELEKSLE----LADSWKRQGDELLYSMIPRPIAERMRLSEEQVCQSFEEVSVI 493
            :.:..:.:..|..||..:|    |..:.:.:.|:|.:.::|.|:...::.:.....:.::||::.
Zfish   710 DNLIRRLQMYSRNLEHLVEERTALYKAERDRADQLNFMLLPGPVVRSLKETGRVEPELYDEVTIY 774

  Fly   494 FLEVMNVYDEGLNSI---QGAMQTVNTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVN- 554
            |.:::     |..:|   ...|:.|:.||.::...|..:....||||||:|..||..||.|..|
Zfish   775 FSDIV-----GFTTICHHSTPMEVVDMLNDIYKNFDSILDHHDVYKVETIGDAYMVASGLPRCNG 834

  Fly   555 PLHAEHACDLALRV---MKKFKAHDMGDVA--IRVGINSGPVVAGVVGQKVPRYCLFGDTVNTAS 614
            ..||...|.:||.:   |..|:...:..:.  ||:||:|||..|||||.|:||||||||||||||
Zfish   835 NRHAVDICLMALDILEFMGTFQLRHLPGIPLWIRIGIHSGPCAAGVVGNKMPRYCLFGDTVNTAS 899

  Fly   615 RMESSSDPWKIQLSKYTGDKVRQ---VGYKVESRGTVQVKGKGDMETYWL 661
            ||||:..|.:|.:|:.| .|:.|   ..::.|.||...:||||...||||
Zfish   900 RMESTGLPLRIHVSEST-IKILQRTDCEFECERRGETFLKGKGKEMTYWL 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	21/91 (23%)
		HNOBA	218..476	CDD:285003	49/327 (15%)
		CYCc	457..643	CDD:214485	71/197 (36%)
		Guanylate_cyc	485..662	CDD:278633	77/188 (41%)
gucy2ca	XP_009297342.1	Periplasmic_Binding_Protein_Type_1	31..365	CDD:299141	13/51 (25%)
		PKc_like	428..698	CDD:304357	45/300 (15%)
		Pkinase_Tyr	451..689	CDD:285015	40/268 (15%)
		CYCc	736..929	CDD:214485	71/198 (36%)
		Guanylate_cyc	763..950	CDD:278633	77/191 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910