DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and adcy3a

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	XP_009290286.1	Gene:	adcy3a / 571825	ZFINID:	ZDB-GENE-111027-6	Length:	1119	Species:	Danio rerio

Alignment Length:	469	Identity:	113/469 - (24%)
Similarity:	195/469 - (41%)	Gaps:	121/469 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 TWIMH-----NPGANPKSFIGT--HVMDLFQCRRPKDTTID-------------------WDTLI 289
            |||.|     |..|....||.|  .::|:..||.|:.:|::                   :.:.|
Zfish   689 TWIDHTRWARNTWAMAAIFIVTLADIVDMLSCRAPQTSTVESTAVPPVVTAIRGCAENPKYYSFI 753

  Fly   290 QMRAVLFEFELIRTGHNRAAYDAVLNMDFENYDEMDLNEAQTMALAKAQEFSESHPVDDDESARE 354
            .:.|::....|::..|               ..::.|....|:|......:|.|...|..:..|.
Zfish   754 AVLALIATTMLVQVSH---------------MVKLTLMLLITVATGAVNIYSWSQTFDLYDLTRF 803

  Fly   355 DEIDPATGERRSSQGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSR 419
            .|             .|..|:..:  |...|  :||:..           :..|....:...|:|
Zfish   804 KE-------------YRVNLVPSK--YTMSV--MIFIMM-----------VSFYYFSRHVEKLAR 840

  Fly   420 ELVMAGWQHCSKLEIMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERM----RLSE 480
            .|.:  |    |:|:    .||:    ||..|:    :|..:.|:.:|:|..:|...    :..|
Zfish   841 TLFL--W----KIEV----HEQK----EKVYEM----RRWNEALVTNMLPEHVARHFLGSKKRDE 887

  Fly   481 EQVCQSFEEVSVIFLEVMNVYD----EGLNSIQGAMQTVNTLNKVFSALDEEIISP---FVYKVE 538
            |...||::|:.|:|..:.|..|    |.:|:  |.::.:..||::.|..|..:..|   .:.|::
Zfish   888 ELYSQSYDEIGVMFASIPNFSDFYTEESINN--GGIECLRFLNEIISDFDSLLDEPQFRCITKIK 950

  Fly   539 TVGMVYMAVSGAPDVNPLHA---------------EHACD-----LALRV-MKKFKAHDMGDVAI 582
            |:|..|||.||....|..:.               :|..|     ||::| :.........:..:
Zfish   951 TIGSTYMAASGVTSDNNTNGYACMKKEEISDRERWQHLADLADFALAMKVTLMNINYQSFNNFML 1015

  Fly   583 RVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGDKVRQVGYKVESRGT 647
            |:|:|.|.|:|||:|.:.|.:.::|:|||.||||||:.....||:.:.....::..|::...||.
Zfish  1016 RIGLNKGAVLAGVIGARKPHFDIWGNTVNVASRMESTGVMGNIQVVEDCYCILKDYGFRFVRRGP 1080

  Fly   648 VQVKGKGDMETYWL 661
            :.|||||::.||:|
Zfish  1081 IFVKGKGELLTYFL 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002
		HNOBA	218..476	CDD:285003	49/250 (20%)
		CYCc	457..643	CDD:214485	59/217 (27%)
		Guanylate_cyc	485..662	CDD:278633	62/205 (30%)
adcy3a	XP_009290286.1	AC_N	<37..304	CDD:292831
		CYCc	273..468	CDD:214485
		Guanylate_cyc	310..492	CDD:278633
		CYCc	858..1075	CDD:214485	60/222 (27%)
		Guanylate_cyc	889..1096	CDD:278633	62/208 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900