DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and adcy7

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	XP_021333246.1	Gene:	adcy7 / 568726	ZFINID:	ZDB-GENE-040713-1	Length:	1119	Species:	Danio rerio

Alignment Length:	331	Identity:	90/331 - (27%)
Similarity:	154/331 - (46%)	Gaps:	77/331 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   397 ENLDELHGIGLYLNDLNPHGLSRELVM--AGWQHCSKL------------EIMFEKEEQ---RSD 444
            |||...:...||.|    |.....|::  ||.....|:            .::..::.:   |.|
Zfish   787 ENLFSNYNCLLYTN----HSCGDSLMVCKAGLMKHPKIMSCIYITLFLFTMLLISRQNEYCCRQD 847

  Fly   445 ELEKSLELADSWKRQGDE-----LLYSMIPRPIAERM-------------------RLSEEQVCQ 485
            .|.|:..|||..:.:..|     ||.:::|..:|...                   |..::...:
Zfish   848 FLLKNKNLADKEEVELCENLNRLLLENVLPAHVAALFVGENKKNEVGLLSAISLLNRKYKDLYYK 912

  Fly   486 SFEEVSVIFLEV---------MNVYDEGLNSIQGAMQTVNTLNKVFSALDEEIISP---FVYKVE 538
            |::.|.|:|..|         .::..|||       :.:..||::.:..||.:..|   .|.|::
Zfish   913 SYDCVCVMFASVPDFKEFYTECDINKEGL-------ECLRLLNEIIADFDELLSKPKFSGVEKIK 970

  Fly   539 TVGMVYMA---VSGAPDVNPLHAE-------HACDLALRVMKK---FKAHDMGDVAIRVGINSGP 590
            |:|..|||   :||.|:.:....|       :..:.|:.::.|   ...|......:|||||.||
Zfish   971 TIGSTYMAAAGLSGPPEQSNQDRERQNAQIGNMVEFAIALIGKLDGINRHSFNTFRLRVGINHGP 1035

  Fly   591 VVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGDKVRQVGYKVESRGTVQVKGKGD 655
            |:|||:|.:.|:|.::|:|||.||||||:.:..|||:::.|...::.:||..|.||.:.|||||:
Zfish  1036 VIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETSIVLQNLGYSCECRGLINVKGKGE 1100

  Fly   656 METYWL 661
            ::|:::
Zfish  1101 LKTFFV 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002
		HNOBA	218..476	CDD:285003	23/100 (23%)
		CYCc	457..643	CDD:214485	63/234 (27%)
		Guanylate_cyc	485..662	CDD:278633	66/202 (33%)
adcy7	XP_021333246.1	AC_N	<129..248	CDD:318454
		Guanylate_cyc	272..455	CDD:306677
		DUF1053	487..613	CDD:310728
		Guanylate_cyc	909..1106	CDD:306677	66/203 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810