DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and gucy1b2

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	XP_685297.5	Gene:	gucy1b2 / 557191	ZFINID:	ZDB-GENE-130530-664	Length:	757	Species:	Danio rerio

Alignment Length:	725	Identity:	191/725 - (26%)
Similarity:	332/725 - (45%)	Gaps:	144/725 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGMLYESVQHYVQEEYGVDIWRKVCHIIDCKHNSFKTHQIYPDKLMPDIAEALSACTGESFDFC 65
            |||.:...::..|.|.:|.:.|..: .::.....:|.|::||.|.:...:.:........|.:..
Zfish     1 MYGFINTCLKSLVIERFGEETWENL-RLMAGVQETFMTYEIYDDIITLRLVQEACKMLDVSSEVV 64

  Fly    66 MNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHLIMRFTYPKMKSPSMQLTNMDDNGAV 130
            :..||..|..|....|||.|:|:.|....:|::::|.:|..:..:|..|.:||.::..|||...:
Zfish    65 LKLFGEYFFSFCKMSGYDTMLRTLGGNLVEFIENLDALHSYLALSYEAMNAPSFRVERMDDGRIL 129

  Fly   131 ILYRSSRTGMSKYLIGQMTEVAREFYGLEIKAYVI-ESQNDISGGTAGPI--------KLT---- 182
            :.|.|.|.|:...:.|.:..||::|:..|:...:: :|:.|...|....:        |:|
Zfish   130 LHYYSDRKGLYHIVPGIIEAVAKDFFDSEVTMTILNQSEEDERTGKKEHVVFHMVQKEKVTKRKA 194

  Fly   183 ----DGPLTVIVKYRLDFDN--REYMAKRVNTEA--------------------------HPSQL 215
                :.....|::.:.|.:.  |...|:..|.:.                          .||..
Zfish   195 QTRQNNSEEEILEVKKDKEETMRRMKARYANLQLCPRKRSPWELVRSIVMLGQGNLRQSFTPSYP 259

  Fly   216 KMPTVKLDVFLDLFPFTFVLNHDMKITHAG---EKIVETWIMHNPGANPKSFIGTHVMDLFQCRR 277
            |...::...|.:.|||..|.:.|:.:.|.|   :|.|       ||...   .|..:.:.|....
Zfish   260 KTLWIEEQAFCNAFPFHIVFDSDLVVKHTGVNIQKFV-------PGLQT---AGIRLDEYFTIVH 314

  Fly   278 PKDTTIDWDTLIQMRAVLFEFELIRTGHNRAAYDAVLNMDF--ENYDEMDLNEAQTMALAKAQEF 340
            |:              |:|..:.|:         ..:|..|  :...|| |.|.|
Zfish   315 PE--------------VIFNIQSIK---------KFINSQFVLKTRREM-LPEVQ---------- 345

  Fly   341 SESHPVDDDESAREDEIDPATGERRSSQGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGI 405
                                       |...::.|:|||.:::.::.:|:||||.:.:|.||...
Zfish   346 ---------------------------QNQPTLKLRGQMMWMESLNCMIYLCSPKLRSLQELEER 383

  Fly   406 GLYLNDLNPHGLSRELVMAGWQHCSKLEI--MFEKEEQRSDELEKSLELADSWKRQGDELLYSMI 468
            ||:|.|:..|..:|:|::...|..:::|:  ..|::::....|.::||:.   |::.::|||:|:
Zfish   384 GLHLADIAQHDTTRDLILLNQQRLAEIELSNQLERKKEELRILSRNLEIE---KQKSEKLLYAML 445

  Fly   469 PRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYDEGLNSIQGA---MQTVNTLNKVFSALDEEII 530
            |..:|.:::..:......|:..:::|.:|:.     ..:|..|   :|.||.||.::|..|....
Zfish   446 PTHVANQLKEGKRVEAGEFKVCTILFSDVVT-----FTNICAACEPIQIVNMLNAMYSRFDRLTS 505

  Fly   531 SPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLALRVMKKFKAHDMGD------VAIRVGINSG 589
            ...||||||:|..||.|.|.|.....|||...:.||.:  :..|.::.:      :.||||:::|
Zfish   506 IHNVYKVETIGDAYMVVGGVPVPTNTHAERVANFALGM--RIAAREVTNPITGQPIQIRVGLHTG 568

  Fly   590 PVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGDKVRQVG-YKVESRGTVQVKGK 653
            ||:|||||:|:||||||||||||||||||...|..|.:|.:|...::..| :::..||.::||||
Zfish   569 PVLAGVVGEKMPRYCLFGDTVNTASRMESHGVPDHIHVSPFTFSVIKDKGIFEMAERGEIEVKGK 633

  Fly   654 GDMETYWLLE 663
            |.|.||:||:
Zfish   634 GLMRTYFLLK 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	41/158 (26%)
		HNOBA	218..476	CDD:285003	58/264 (22%)
		CYCc	457..643	CDD:214485	73/195 (37%)
		Guanylate_cyc	485..662	CDD:278633	76/186 (41%)
gucy1b2	XP_685297.5	HNOB	2..163	CDD:285002	41/161 (25%)
		CAF-1_p150	<166..277	CDD:288454	17/110 (15%)
		HNOBA	269..453	CDD:285003	58/257 (23%)
		CYCc	432..618	CDD:214485	72/195 (37%)
		Guanylate_cyc	459..642	CDD:278633	76/189 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.780