DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Da and Gucy1b1

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_059497.1	Gene:	Gucy1b1 / 54195	MGIID:	1860604	Length:	620	Species:	Mus musculus

Alignment Length:	693	Identity:	200/693 - (28%)
Similarity:	321/693 - (46%)	Gaps:	120/693 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGMLYESVQHYVQEEYGVDIWRKVCHIIDCK-------HNSFKTHQIYPDKLMPDIAEALSACT 58
            |||.:..:::..|...||.::|.      |.|       ...|....||.|....|:..|.|...
Mouse     1 MYGFVNHALELLVIRNYGPEVWE------DIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVL 59

  Fly    59 GESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHLIMRFTYPKMKSPSMQLTN 123
            ..:....:..||:.|..|....|||.::|..|....:|||::|.:|..:...||.|::||.:.|:
Mouse    60 NLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTD 124

  Fly   124 MD-DNGAVILYRSSRTGMSKYLIGQMTEVAREFYGLEIKAYVIESQNDISGGTAGPIKLTDGPLT 187
            .: ..|.::.|.|.|.|:...:||.:..||::.:|.||...||:.:|:....|         ...
Mouse   125 AEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHT---------QFL 180

  Fly   188 VIVKYRLDFDNREYMAKRVNTEAHPSQLKMPTVKLDVFLDLFPFTFVLNHDMKITHAGEKIVETW 252
            :..|...:.|..|.:.:........|::...|     |...|||..:.:.::.:|..|..|....
Mouse   181 IEEKESKEEDFYEDLDRFEENGTQESRISPYT-----FCKAFPFHIIFDRNLVVTQCGNAIYRVL 240

  Fly   253 IMHNPGANPKSFIGTHVMDLFQCRRPKDTTIDWDTLIQMRAVLFEFELIRTGHNRAAYDAVLNMD 317
            ....||               .|                 ::|..|.|:|. |...::..:
Mouse   241 PQLQPG---------------NC-----------------SLLSVFSLVRP-HIDISFHGI---- 268

  Fly   318 FENYDEMDLNEAQTMALAKAQEFSESHPVDDDESAREDEIDPATGERRSSQGLRSILLKGQMFYI 382
                    |:...|:.:.:::|    ..:|.::...|||:   ||..     :..:.|||||.|:
Mouse   269 --------LSHINTVFVLRSKE----GLLDVEKLECEDEL---TGAE-----ISCLRLKGQMIYL 313

  Fly   383 KDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQH------CSKLEIMFEKEEQ 441
            .:.||::|||||.:.|||:|...||||:|:..|..:|:||:.|.|.      ..:|||:
Mouse   314 PEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEIL------ 372

  Fly   442 RSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVM--NVYDEG 504
             :|.|:.:|...:..|::.|.||||::|..:|..:|.......:.::.|:::|..::  |.:...
Mouse   373 -TDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSK 436

  Fly   505 LNSIQGAMQTVNTLNKV---FSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLAL 566
            ..|.:|||:.||.||.:   |..|.:...:||||||||||..||.|||.|:....||...|.|||
Mouse   437 HASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLAL 501

  Fly   567 RVMK---KFKAHDMGDVAIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLS 628
            .:|:   :.:. |...|.|.:||::|.||.||:||::|||||||:|||..||.|::.:..||.:|
Mouse   502 DMMEIAGQVQV-DGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVS 565

  Fly   629 KYT---------GDKVRQVGYKVESRGTVQVKGKGDMETYWLL 662
            :||         .|.:    :.:|.||.|.:|||.:....|.|
Mouse   566 EYTYRCLMSPENSDPL----FHLEHRGPVSMKGKKEPMQVWFL 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	46/166 (28%)
		HNOBA	218..476	CDD:285003	67/263 (25%)
		CYCc	457..643	CDD:214485	76/202 (38%)
		Guanylate_cyc	485..662	CDD:278633	75/193 (39%)
Gucy1b1	NP_059497.1	HNOB	2..166	CDD:311572	47/169 (28%)
		HNOBA	207..406	CDD:311573	67/267 (25%)
		Guanylate_cyc	412..605	CDD:306677	76/198 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4189
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.770