Protein Alignment Gyc89Da and NPR1

DIOPT Version :10

• Sequence 1: NP_001036718.1
• Gene: Gyc89Da / 42001
• FlyBaseID: FBgn0038435
• Length: 667
• Species: Drosophila melanogaster
• Sequence 2: NP_000897.3
• Gene: NPR1 / 4881
• HGNCID: 7943
• Length: 1061
• Species: Homo sapiens
• Alignment Length: 606
• Identity: 156/606 - (25%)
• Similarity: 240/606 - (39%)
• Gaps: 197/606 - (32%)

  Fly   173 GGTAGPIKLTDGPLTVIVKYRLDFDNREYMAKRVNTEAHPSQLKMPTVKLDVFLDLFPFTFVLNH 237
            |...|.:..|:|...|..|... :.......||||.:......|:              .|.|.|
Human   537 GSNYGSLLTTEGQFQVFAKTAY-YKGNLVAVKRVNRKRIELTRKV--------------LFELKH 586

  Fly   238 --DMKITHAGEKIVETWIMHNPGANPKSFIGTHVMDLFQCRRP---------------------K 279
              |::..|.                 ..|:|.       |..|                     :
Human   587 MRDVQNEHL-----------------TRFVGA-------CTDPPNICILTEYCPRGSLQDILENE 627

  Fly   280 DTTIDWDTLIQMRAVLFEFEL---IRTG----HNRA--------AYDAVLNMDF---------EN 320
            ..|:||         :|.:.|   |..|    ||.|        :.:.|::..|         |:
Human   628 SITLDW---------MFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLES 683

  Fly   321 YDEMDLNEAQTMALAKAQEFSE-----SHPVDDDESAREDEIDPATGERRSSQG---------LR 371
            :.::|..:..|:...|.....|     |.||                  |.||.         |:
Human   684 FRDLDPEQGHTVYAKKLWTAPELLRMASPPV------------------RGSQAGDVYSFGIILQ 730

  Fly   372 SILLKGQMFYIKDVDSLIFLCSP--LIENL---------------DELHGIGLYL---------- 409
            .|.|:..:|:::.:|     .||  :||.:               ..|..:||.:
Human   731 EIALRSGVFHVEGLD-----LSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQE 790

  Fly   410 --------------NDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLELADSWKRQG 460
                          |..|...:...|:....|:.:.||.:.|:..|.  .||:        ||:.
Human   791 RPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQA--YLEE--------KRKA 845

  Fly   461 DELLYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYDEGLNSIQGAMQTVNTLNKVFSAL 525
            :.|||.::|..:||:::..|....::|:.|::.|.:::..  ..|::....||.|..||.:::..
Human   846 EALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGF--TALSAESTPMQVVTLLNDLYTCF 908

  Fly   526 DEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLA------LRVMKKFKA--HDMGDVAI 582
            |..|.:..||||||:|..||.|||.|..|  ...|||::|      |..::.|:.  .....:.:
Human   909 DAVIDNFDVYKVETIGDAYMVVSGLPVRN--GRLHACEVARMALALLDAVRSFRIRHRPQEQLRL 971

  Fly   583 RVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGDKVRQV-GYKVESRG 646
            |:||::|||.|||||.|:||||||||||||||||||:.:..||.||..|...:.:. |:::|.||
Human   972 RIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRG 1036

  Fly   647 TVQVKGKGDMETYWLLEGPEG 667
            .|::||||.:.||||| |..|
Human  1037 DVEMKGKGKVRTYWLL-GERG 1056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:462233
		HNOBA	218..476	CDD:462234	62/359 (17%)
		Nucleotidyl_cyc_III	485..662	CDD:448371	78/185 (42%)
NPR1	NP_000897.3	PBP1_NPR_A	36..443	CDD:380608
		PK_GC-A_B	534..807	CDD:270944	56/340 (16%)
		HNOBA	<813..861	CDD:462234	16/57 (28%)
		CYCc	840..1032	CDD:214485	77/203 (38%)