DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Da and Gycalpha99B

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster

Alignment Length:	689	Identity:	152/689 - (22%)
Similarity:	283/689 - (41%)	Gaps:	178/689 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KVC----HIIDCKHNSFKTHQIYPDKLMPDIAEALSACTGESFDFCMNFFGRCFVRFFSNFGYDK 84
            |.|    ::.|.:....|..:....:::..:.|.|..|.      |.....|.|
  Fly    87 KSCANYDYLADIQELLLKMDEASASEILVLLGEELITCC------CTGIIERAF----------- 134

  Fly    85 MIRSTGRYFCDFLQSIDNIHLIMRFTYPKMKSPSMQLTNMDDNGAV------ILYRSSRTGMSKY 143
              |..|....:||.|:|.::.:::          :|..::.|.|.|      :::.|.|..::..
  Fly   135 --RCLGTDLQEFLGSLDGVYDVLK----------LQEEDVTDTGFVCAGEGELIFTSERPVIAWL 187

  Fly   144 LIGQMTEVAREFYGLEIKAYVIESQNDISGGTAGPIKLTDGPLTVIVKYRLDF----DNREYM-- 202
            |:|.:..:.|..|.:::...:...:.|..                  :||..|    ||.:.|
  Fly   188 LLGSLKALTRMLYKVDVNIKIEPVEGDAR------------------RYRYLFSLVKDNSQTMLM 234

  Fly   203 -------------AKRVNTEAHPSQLKMPTVKLDVFLDLFPFTFVLNHDMKITHAG---EKIVET 251
                         .:|.|: ::.|.|:|.:   ..|..:||:.|::|..:::...|   .|:.:.
  Fly   235 GRPTSVSKTIPETVQRSNS-SNASDLQMNS---SSFCKMFPWHFIMNEQLELVQLGRGFSKLYKP 295

  Fly   252 WIMHNPGANPKSFIGTHVMDLFQCRRPKDTTIDWDTLIQMRAVLFEFELIRTGHNRAAYDAVLNM 316
            ::         :..|......|..:|||..|:.:..:::.....|   ||...:...|      :
  Fly   296 YM---------ADFGCQATTYFDFKRPKGLTMKFRDIVRRTYTPF---LIGLNNPPGA------V 342

  Fly   317 DFENYDEMDLNEAQTMALAKAQEFSESHPVDDDESAREDEIDPATGERRSSQGLRSILLKGQMFY 381
            ||                                        ||.|          :.:||||.:
  Fly   343 DF----------------------------------------PAIG----------LEIKGQMVH 357

  Fly   382 IKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDEL 446
            ..:.:||:|:.||.::.||.|...||:::|:..|..:||:::.|.|..::     :...:|.|::
  Fly   358 CPESNSLLFIGSPFLDGLDGLTCNGLFISDIPLHDATREVILVGEQARAQ-----DGLRRRMDKI 417

  Fly   447 EKSLELADS----WKRQGDELLYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYDEGLNS 507
            :.|:|.|:|    .:::...||:.:.|..|||::.|......:::.:|:::|.:::     |..|
  Fly   418 KNSIEEANSAVTKERKKNVSLLHLIFPAEIAEKLWLGSSIDAKTYPDVTILFSDIV-----GFTS 477

  Fly   508 I---QGAMQTVNTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLALRVM 569
            |   ......::.|..::...||......||||||:|..|...||....:...|.....:||:::
  Fly   478 ICSRATPFMVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGLHRASIYDAHKVAWMALKMI 542

  Fly   570 ---KKFKAHDMGDVAIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYT 631
               .|...||...:.:|:|:::|.|:|||||:|:|||||||.:|..|::.||.|:..||.:|..|
  Fly   543 DACSKHITHDGEQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTT 607

  Fly   632 GD-KVRQVGYKVE------SRGTVQVKGKGDMETYWLLE 663
            .| ..:..|::.|      |....:....|..||.:.||
  Fly   608 KDWLTKHEGFEFELQPRDPSFLPKEFPNPGGTETCYFLE 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	26/146 (18%)
		HNOBA	218..476	CDD:285003	54/264 (20%)
		CYCc	457..643	CDD:214485	59/192 (31%)
		Guanylate_cyc	485..662	CDD:278633	57/189 (30%)
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002	26/149 (17%)
		HNOBA	259..451	CDD:285003	56/267 (21%)
		CYCc	430..619	CDD:214485	59/193 (31%)
		Guanylate_cyc	457..647	CDD:278633	59/195 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454038
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D24411at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45655
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850