DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and CG33958

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	149/546 - (27%)
Similarity:	236/546 - (43%)	Gaps:	158/546 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 DFDNREYMAKRVNTEAHPSQLKMPTVKLDVFLD---LFP----FTFVLNHDMKIT-----HAGEK 247
            |.|:||.|..|...::          :|:.|.|   |.|    .|.|:|....|.     |..|:
  Fly   213 DEDDREMMLNRYEFQS----------RLNEFRDRVRLEPEESSITEVMNWYTSINRGLLHHLSEQ 267

  Fly   248 IVETWIMHNPGA---------------------------------NPKSFIGTHVMDLFQCRRPK 279
            |.||   .|.|.                                 ..::|: ::|...|..|...
  Fly   268 IKET---DNSGVWRYLVGFKNLLKSIECQNIATSFGIRYYGRGSLTAENFV-SYVRYEFMAREMI 328

  Fly   280 DTTIDWDTLIQ------------MRAVLFEFELIRTGHN----RAA--YDAVLNMDFENYDEMDL 326
            ::|:::..:::            .||......|::...|    |:|  |..::|    ||.: ||
  Fly   329 NSTLNYAPMLKNMYTNITSTKKFHRAKQMGTTLLKNNPNVSNERSAIEYYELMN----NYTD-DL 388

  Fly   327 NEAQTMALAKAQEFSESHPVDDDESAREDEIDPATGERRSSQGLRSILLKGQMFYIKDVDSLIFL 391
            ...|.......:|:.:...|:.|              |:.:.|: :||:            ::.:
  Fly   389 RILQKALRRLIKEYVDKTLVEAD--------------RKEAIGI-AILV------------VVLI 426

  Fly   392 CSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLELADSW 456
            .||:|..|.:.....:.|..||   ||                      |::.||::.
  Fly   427 VSPVIIVLVKNAAATIQLYALN---LS----------------------QKAKELKRE------- 459

  Fly   457 KRQGDELLYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYDEGLNSIQG---AMQTVNTL 518
            ||:.|.||:.|:|..:|.:::.:::...:.:|.|::.|.:::     |...|..   .::.|..|
  Fly   460 KRKSDSLLFQMLPPSVAMQLKQTQQVPAELYEAVTIYFSDIV-----GFTEIAADCTPLEVVTFL 519

  Fly   519 NKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVN-PLHAEHACDLALRVM---KKFKAHDMGD 579
            |.::...||.|....||||||:|..||..||.|..| ..|......:||.::   ..|:....||
  Fly   520 NSIYRVFDERIECYDVYKVETIGDSYMVASGLPVKNGNKHISEIATMALDLLDASSVFRIPRAGD 584

  Fly   580 --VAIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGDKVRQV-GYK 641
              |.||.|:::||||||:||.|:||||||||||||||||||:.:..||.:::...|.::|| |::
  Fly   585 EFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVGGFR 649

  Fly   642 VESRGTVQVKGKGDMETYWLL--EGP 665
            .|.||.:.|||||.|.||||.  :||
  Fly   650 TEHRGLIDVKGKGLMSTYWLTCKDGP 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002
		HNOBA	218..476	CDD:285003	61/320 (19%)
		CYCc	457..643	CDD:214485	75/195 (38%)
		Guanylate_cyc	485..662	CDD:278633	79/186 (42%)
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	40/201 (20%)
		HNOBA	<439..479	CDD:285003	16/71 (23%)
		CYCc	459..647	CDD:214485	74/199 (37%)
		Guanylate_cyc	485..669	CDD:278633	78/188 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D531253at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.820